ST6GALNAC1 Gene Summary [Human]
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ST6GALNAC1 |
| Official Name | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23614] |
| Ensembl ID | ENSG00000070526 |
| Bio databases IDs | |
| Aliases | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
| Synonyms | HSY11339, Sialyltransferase 7A, SIAT7A, ST6GALNACI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, ST6 N-acetylgalactosaminide α-2,6-sialyltransferase 1, STYI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ST6GALNAC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- inflammatory bowel disease
- aortic valve calcification
- latent tuberculosis
role in cell
- expression in
- degradation in
- adhesion
- substrate adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ST6GALNAC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- homeostasis of number of cells in a free-living population
- protein glycosylation
- oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
- protein binding
- sialyltransferase activity