Snap25 Gene Summary [Mouse]
Enables SNAP receptor activity and syntaxin-1 binding activity. Involved in presynaptic dense core vesicle exocytosis and regulation of neuron projection development. Acts upstream of or within several processes, including associative learning; long-term synaptic potentiation; and neurotransmitter secretion. Located in several cellular components, including presynaptic membrane; synaptic vesicle; and trans-Golgi network. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is active in glutamatergic synapse. Is expressed in adrenal gland; jaw; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; obesity; schizophrenia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snap25 |
| Official Name | synaptosomal-associated protein 25 [Source:MGI Symbol;Acc:MGI:98331] |
| Ensembl ID | ENSMUSG00000027273 |
| Bio databases IDs | |
| Aliases | synaptosomal-associated protein 25 |
| Synonyms | bA416N4.2, BDR, CMS18, dJ1068F16.2, GENA70, RIC-4, SEC9, SNAP, Snap25a, sp, SUP, synaptosomal-associated protein 25, synaptosome associated protein 25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snap25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- SNAP receptor
- SNAP-25 family
- calcium-dependent protein binding
- palmitoylation site
- lipid binding
- helical domain
- coiled-coil domain
- protein domain specific binding
- protein binding
- zDHHC ankyrin repeat binding domain
- myosin binding
- voltage-gated potassium channel
- cytoplasmic domain
- syntaxin-1 binding
- Helical region found in SNAREs
- transmembrane domain
- ion channel binding
- SNARE motif
- transporter
Pathways
Biological processes and signaling networks where the Snap25 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- weight loss
- cluster headache
- neurodegeneration
- obesity
- myofascial pain
- temporomandibular joint disorder
- Huntington disease
- upper limb spasticity
- scleroderma
phenotypes
- abnormal CNS synaptic transmission
- abnormal PNS synaptic transmission
- abnormal blood vessel morphology
- abnormal brain morphology
- abnormal cerebral cortex morphology
- abnormal dopamine level
- abnormal endplate potential
- abnormal hippocampus CA3 region morphology
- abnormal impulsive behavior control
- abnormal insulin secretion
- abnormal intercostal muscle morphology
- abnormal locomotor behavior
- abnormal miniature excitatory postsynaptic currents
- abnormal motor capabilities/coordination/movement
- abnormal object recognition memory
- abnormal pancreatic beta cell physiology
- abnormal serotonin level
- abnormal skin condition
- abnormal spatial learning
- akinesia
- ataxia
- blotchy skin
- convulsive seizures
- decreased body size
- decreased body weight
- decreased circulating ghrelin level
- decreased embryo size
- decreased food intake
- decreased glucagon secretion
- decreased insulin secretion
- decreased paired-pulse facilitation
- decreased prepulse inhibition
- decreased synaptic glutamate release
- decreased vertical activity
- decreased width of hypertrophic chondrocyte zone
- delayed eyelid opening
- disheveled coat
- enhanced paired-pulse facilitation
- hepatic steatosis
- hyperactivity
- hyperglycemia
- hypoactivity
- impaired coordination
- impaired hearing
- improved glucose tolerance
- increased anxiety-related response
- increased body mass index
- increased body weight
- increased circulating cholesterol level
- increased circulating insulin level
- increased circulating leptin level
- increased circulating triglyceride level
- increased food intake
- increased susceptibility to diet-induced obesity
- increased thigmotaxis
- increased white adipose tissue amount
- increased white fat cell size
- infertility
- insulin resistance
- myoclonus
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- no spontaneous movement
- postnatal lethality incomplete penetrance
- premature death
- respiratory failure
- seizures
- thin diaphragm muscle
- tremors
- unresponsive to tactile stimuli
role in cell
- growth
- synthesis in
- apoptosis
- invasion by
- survival
- abnormal morphology
- accumulation
- endocytosis by
- fusion
- fusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- early endosomal fractions
- intracellular membrane fractions
- myelin enriched fraction
- synaptic plasma membrane fractions
- detergent-soluble membrane fractions
- membrane fraction
- glutaminergic synapse
- axon component
- cytoskeleton
- Cytoplasm
- synaptic cleft
- cell surface
- intracellular space
- basal compartment
- somatodendritic region
- perinuclear region
- microvesicles
- intracellular membranes
- cellular membrane
- actin cytoskeleton
- cell cortex
- endosomes
- vesicles
- granules
- tertiary granule membrane
- granule membrane
- specific granule membrane
- cytosol
- microsome
- apical membrane
- presynaptic membrane
- trans Golgi network
- synaptic vesicles
- neuromuscular junctions
- growth cone
- neurites
- nerve ending
- synaptosomes
- synapse
- recycling endosomes
- early endosomes
- transport vesicles
- cellular protrusions
- filopodia
- motor endplates
- perikaryon
- axons
- axon terminals
- presynaptic terminals
- ribbon synapse
- exosomes
- clathrin-coated vesicles
- dense core granules
- perinuclear recycling endosome
- lamellipodia
- mossy fibers
- detergent-soluble fraction
- endosomes and endoplasmic reticulum fractions
- synaptic vesicle fractions
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snap25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- SNARE complex assembly
- synaptic transmission
- associative learning
- exocytosis
- long-term memory
- regulation of insulin secretion
- synaptic vesicle docking involved in exocytosis
- locomotory behavior
- synaptic vesicle priming
- axonogenesis
- neurotransmitter uptake
- synaptic vesicle fusion to presynaptic membrane
- endosomal transport
- long-term synaptic potentiation
- synaptic vesicle exocytosis
- positive regulation of insulin secretion
- regulation of neuron projection development
- regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- BLOC-1 complex
- synaptic vesicle
- neuronal cell body
- neuron projection
- growth cone
- trans-Golgi network
- endosome
- synaptobrevin 2-SNAP-25-syntaxin-1a complex
- actin cytoskeleton
- cytosol
- tertiary granule membrane
- lamellipodium
- specific granule membrane
- voltage-gated potassium channel complex
- presynaptic active zone membrane
- plasma membrane
- perinuclear region of cytoplasm
- cytoskeleton
- cytoplasm
- axonal growth cone
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
- cell cortex
- membrane
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
- filopodium
- vesicle
- SNARE complex
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein domain specific binding
- protein binding
- syntaxin-1 binding
- myosin binding
- calcium-dependent protein binding
- SNAP receptor activity
- lipid binding
- ion channel binding