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ESRRA
ESRRA Gene Summary
The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]
Details
| Type | Protein Coding |
| Official Symbol | ESRRA |
| Official Name | estrogen related receptor alpha [Source:HGNC Symbol;Acc:HGNC:3471] |
| Ensembl ID | ENSG00000173153 |
| Bio databases IDs | |
| Aliases | estrogen related receptor alpha |
| Synonyms | ERR1,ERRa,ERRalpha,Errra,ERR α,ERR α 1,ESRL1,estrogen related receptor alpha,estrogen related receptor, alpha,estrogen related receptor α,estrogen related receptor, α,Estrra,NR3B1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- LXXLL motif
- DNA binding domain
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- nucleic acid binding
- AF-2 transcription activation domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- ligand-binding domain
- double-stranded DNA binding
- a/b binding pocket
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the ESRRA gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- RNA polymerase II
- KAT2B
- NCOA1
- TP53
- LDHA
- KRTAP9-2
- PKM
- PPARGC1A
- HIF1A
disease
- schizophrenia
- neoplasia
- obesity
- advanced cancer
- epithelial neoplasia
- cancer
- osteoporosis
- heart failure
- breast cancer
- cholangiocarcinoma cancer
regulated by
- PPARA
- IL1B
- ESR1
- mono-(2-ethylhexyl)phthalate
- diethylstilbestrol
- beta-estradiol
- lipopolysaccharide
- forskolin
- HTT
- NCOA1
regulates
- TNF
- Ca2+
- PTGS2
- reactive oxygen species
- lipid
- IL6
- HMOX1
- FASLG
- SMAD2/3
- CXCR4
role in cell
- quantity
- cell death
- number
- expression in
- size
- cell viability
- growth
- production in
- proliferation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule cytoskeleton
- fibrillar center
- Cytoplasm
- cytoplasmic bridges
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ESRRA gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- intracellular steroid hormone receptor signaling pathway
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- microtubule cytoskeleton
- cytoplasm
- chromatin
- fibrillar center
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein domain specific binding
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- estrogen response element binding
- steroid hormone receptor activity
- sequence-specific DNA binding
- steroid binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity