Il18bp Gene Summary [Rat]
Predicted to enable interleukin-18 binding activity. Involved in cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in extracellular space. Human ortholog(s) of this gene implicated in allergic contact dermatitis and myocardial infarction. Orthologous to human IL18BP (interleukin 18 binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il18bp |
| Official Name | interleukin 18 binding protein [Source:RGD Symbol;Acc:620042] |
| Ensembl ID | ENSRNOG00000020150 |
| Bio databases IDs | |
| Aliases | interleukin 18 binding protein |
| Synonyms | FVH, IGIFBP, IL18BP isoform 2, interleukin 18 binding protein, MC54L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il18bp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-18 binding
- Orthopoxvirus interleukin 18 binding protein
- receptor antagonist activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- cancer
- metastasis
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
- anemia
- advanced cancer
- contact hypersensitivity
- susceptibility to fulminant viral hepatitis
- weight loss
role in cell
- production in
- binding in
- quantity
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il18bp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T-helper 1 type immune response
- response to lipopolysaccharide
- cellular response to tumor necrosis factor
- cellular response to hydrogen peroxide
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- receptor antagonist activity
- interleukin-18 binding