Ccnd2 Gene Summary [Mouse]
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and protein kinase binding activity. Acts upstream of or within several processes, including adult locomotory behavior; cellular response to X-ray; and long-term memory. Located in nucleus. Part of cyclin D2-CDK4 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); ductal carcinoma in situ; hepatitis B; and liver cancer (multiple). Orthologous to human CCND2 (cyclin D2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccnd2 |
| Official Name | cyclin D2 [Source:MGI Symbol;Acc:MGI:88314] |
| Ensembl ID | ENSMUSG00000000184 |
| Bio databases IDs | |
| Aliases | cyclin D2 |
| Synonyms | 2600016F06RIK, AI256817, cD2, cyclin D2, CYL2, KIAK0002, MPPH3, Vin-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccnd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- pRb binding domain
- protein kinase binding
- Cyclin box fold superfamily
- Cyclin, N-terminal domain
- protein binding
- LXCXE binding site
- domain present in cyclins, TFIIB and Retinoblastoma
- cyclin-dependent protein kinase regulator
Pathways
Biological processes and signaling networks where the Ccnd2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Breast Cancer Regulation by Stathmin1
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Endocannabinoid Cancer Inhibition Pathway
- Erythropoietin Signaling
- GADD45 Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- p53 Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Role of JAK2 in Hormone-like Cytokine Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- epithelial cancer
- cancer
- Alzheimer disease
- neoplasia
- metastatic breast cancer
- non-insulin-dependent diabetes mellitus
- HER2 negative hormone receptor negative breast cancer
- schizophrenia
- colorectal adenoma
phenotypes
- abnormal cranium morphology
- abnormal spine curvature
- decreased body weight
- decreased spleen weight
- decreased total body fat amount
- hyperactivity
- impaired glucose tolerance
- increased bone mineral content
- increased bone mineral density
- increased circulating alkaline phosphatase level
- increased circulating iron level
- increased fasting circulating glucose level
- increased grip strength
- increased lean body mass
- increased mean corpuscular volume
- small testis
- trunk curl
- abnormal Purkinje cell dendrite morphology
- abnormal Purkinje cell morphology
- abnormal adipose tissue amount
- abnormal body weight
- abnormal bone mineral density
- abnormal cerebellar foliation
- abnormal cerebellar granule layer morphology
- abnormal cerebellar molecular layer
- abnormal cerebellum external granule cell layer morphology
- abnormal cerebellum morphology
- abnormal grip strength
- abnormal lean body mass
- abnormal mean corpuscular volume
- abnormal ovarian folliculogenesis
- abnormal ovulation
- abnormal spleen weight
- decreased bone mineral content
- decreased testis weight
- female infertility
- oligozoospermia
- small cerebellum
- thin external granule cell layer
- thrombocytosis
role in cell
- proliferation
- growth
- apoptosis
- expression in
- cell death
- activation in
- phosphorylation in
- differentiation
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccnd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-term memory
- cell division
- positive regulation of cyclin-dependent protein kinase activity
- cellular response to X-ray
- positive regulation of G1/S transition of mitotic cell cycle
- negative regulation of apoptotic process
- positive regulation of cell proliferation
- G1/S transition of mitotic cell cycle
- positive regulation of protein phosphorylation
- adult locomotory behavior
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- centrosome
- cytoplasm
- cyclin-dependent protein kinase holoenzyme complex
- cyclin D2-CDK4 complex
- cytosol
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- cyclin-dependent protein kinase regulator activity
- protein binding