Cbx3 Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity and transcription cis-regulatory region binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in chromocenter; chromosome, centromeric region; and nuclear envelope. Is expressed in several structures, including central nervous system; embryo ectoderm; gonad; gut; and retina nuclear layer. Orthologous to human CBX3 (chromobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbx3 |
| Official Name | chromobox 3 [Source:MGI Symbol;Acc:MGI:108515] |
| Ensembl ID | ENSMUSG00000029836 |
| Bio databases IDs | |
| Aliases | chromobox 3 |
| Synonyms | chromobox 3, HECH, HP1g, HP1-GAMMA, HP1Hs-gamma, HP1Hs-γ, HP1-γ, M32 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cbx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- transcription regulator
- nucleic acid binding
- enzyme binding
- transcription factor binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- Chromo shadow domain
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- serine-rich region
- double-stranded DNA binding
- hinge domain
- Chromo (CHRromatin organization MOdifier) domain
Pathways
Biological processes and signaling networks where the Cbx3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- small cell lung cancer
- glioblastoma
- glioblastoma cancer
- tumorigenesis
- breast cancer
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- organismal death
role in cell
- apoptosis
- expression in
- proliferation
- phosphorylation in
- migration
- differentiation
- trimethylation in
- invasion by
- accumulation in
- palbociclib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- spindle apparatus
- Cytoplasm
- chromosome
- nucleoplasm
- nucleoli
- nuclear envelope
- nuclear speckles
- mitotic spindle
- centromeres
- telomeres
- chromatin
- pericentric heterochromatin
- heterochromatin fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cbx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- rhythmic process
- negative regulation of transcription, DNA-dependent
- heterochromatin assembly
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- condensed chromosome, centromeric region
- chromosome, centromeric region
- chromatin
- centromeric heterochromatin
- nucleoplasm
- nuclear envelope
- chromosome, telomeric region
- nucleus
- heterochromatin
- nuclear inner membrane
- euchromatin
- spindle
Molecular Function
What the gene product does at the molecular level
- transcription cofactor binding
- protein domain specific binding
- identical protein binding
- protein binding
- methylated histone residue binding
- chromatin binding
- enzyme binding