Ctla4 Gene Summary [Rat]
Involved in negative regulation of T cell proliferation. Predicted to be located in several cellular components, including Golgi apparatus; clathrin-coated endocytic vesicle; and perinuclear region of cytoplasm. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in external side of plasma membrane. Used to study myocarditis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); graft-versus-host disease; hematologic cancer (multiple); kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctla4 |
| Official Name | cytotoxic T-lymphocyte-associated protein 4 [Source:RGD Symbol;Acc:61975] |
| Ensembl ID | ENSRNOG00000054129 |
| Bio databases IDs | |
| Aliases | cytotoxic T-lymphocyte-associated protein 4 |
| Synonyms | ALPS5, CD, CD152, CELIAC3, cytotoxic T-lymphocyte-associated protein 4, GRD4, GSE, IDDM12, LOC100048844, Ly-56, sCTLA4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctla4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YVKM motif
- extracellular domain
- lysine rich domain
- Immunoglobulin V-Type
- immunoglobulin domain
- met-tyr-pro-pro-pro-tyr motif
- ectodomain
- central domain
- protein binding
- phosphorylation site
- B7.1/B7.2 ligand-binding domain
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin like
- intracellular domain
- tail domain
- cytosolic tail domain
- transmembrane receptor
- tyrosine phosphorylation site
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Ctla4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic rectal cancer
- osteoporosis
- colorectal cancer
- neoplasia
- rheumatoid arthritis
- epithelial cancer
- epithelial neoplasia
- cancer
- diarrhea
- non-squamous lung carcinoma
phenotypes
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
- B-Cell Chronic Lymphocytic Leukemia
- Behcet's disease
- Bronchial Hyperreactivity
- Bronchitis Chronic
- Diabetic Nephropathies
- Experimental Arthritis
- Experimental Autoimmune Encephalomyelitis
- Experimental Autoimmune Uveitis
- Experimental Melanoma
- Graft vs Host Disease
- Graves Ophthalmopathy
- Graves Disease
- Hashimoto Disease
- Inflammation
- Kidney Reperfusion Injury
- Latent Autoimmune Diabetes in Adults
- Lymphatic Metastasis
- Neoplasm Metastasis
- Prostatic Neoplasms
- Sjogren's Syndrome
- Transplant Rejection
- acute myeloid leukemia
- allergic rhinitis
- Alopecia Areata
- anti-basement membrane glomerulonephritis
- asthma
- atopic dermatitis
- autoimmune hemolytic anemia
- autoimmune thyroiditis
- basal cell carcinoma
- breast cancer
- Celiac Disease
- chronic obstructive pulmonary disease
- contact dermatitis
- end stage renal failure
- granulomatosis with polyangiitis
- immunoglobulin alpha deficiency
- Iridocyclitis
- kidney disease
- lung disease
- Lupus Nephritis
- melanoma
- monoclonal gammopathy of uncertain significance
- Multiple Myeloma
- Multiple Sclerosis
- Myocardial Infarction
- Myocarditis
- non-Hodgkin lymphoma
- primary biliary cirrhosis
- primary immunodeficiency disease
- psoriasis
- renal cell carcinoma
- Rhinitis
- Sarcoidosis
- Silicosis
- squamous cell carcinoma
- type 1 diabetes mellitus
- urinary schistosomiasis
- Vitiligo
- Alcoholic Liver Diseases
- Cryptogenic Cirrhosis
- Enterocolitis
- Hepatitis B Chronic
- Hepatitis C Chronic
- Lymphadenopathy
- Splenomegaly
- autoimmune hepatitis
- Hepatitis B
- hepatocellular carcinoma
- Chronic Bronchitis
- Chronic Hepatitis B
- Chronic Hepatitis C
- end stage renal disease
- anogenital venereal wart
- hepatitis A
- Malaria
- primary biliary cholangitis
- tropical spastic paraparesis
role in cell
- number
- production in
- synthesis in
- survival
- expression in
- phosphorylation in
- differentiation
- cell death
- activation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- endosomes
- lysosome
- Golgi Apparatus
- granules
- plasma membrane extracellular face
- lysosomal compartment
- perinuclear space
- early endosomes
- endocytotic vesicle
- secretory granules
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctla4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- negative regulation of B cell proliferation
- negative regulation of regulatory T cell differentiation
- negative regulation of T cell proliferation
- positive regulation of apoptotic process
- adaptive immune response
- response to DNA damage stimulus
- T cell receptor signaling pathway
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- external side of plasma membrane
- Golgi apparatus
- clathrin-coated endocytic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding