ARHGEF17
ARHGEF17 Gene Summary
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within actin cytoskeleton organization. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARHGEF17 |
| Official Name | Rho guanine nucleotide exchange factor 17 [Source:HGNC Symbol;Acc:HGNC:21726] |
| Ensembl ID | ENSG00000110237 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 17, Rho-specific guanine-nucleotide exchange factor 164 kDa, tumor endothelial marker 4 |
| Synonyms | 8030463K16,AI428794,AW558066,mKIAA0337,P164RHOGEF,RHOGEF17,Rho guanine nucleotide exchange factor 17,TEM4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- central domain
- protein binding
- Dbl homology domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the ARHGEF17 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MYH9
- ANLN
- LBR
- RHOA
- RASL12
- YWHAH
- H1-5
- FHL2
- USP7
- MYH10
disease
- cancer
- neoplasia
- chronic obstructive pulmonary disease
- metastasis
- advanced cancer
- organismal death
- early missed abortion
regulated by
- KCNJ2
- TNF
- FTO
- Pertussis toxin
- VEGF
- CTNNβ/CDHE/N
- TTK
- G protein beta gamma core
- OTUB1
- lysophosphatidic acid
regulates
- FOS
- RAC
- RHOA
- TTK
role in cell
- activation in
- motility
- migration
- formation
- invasion by
- organization
- spindle checkpoint in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ARHGEF17 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- actin cytoskeleton organization
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity