ARHGDIB
ARHGDIB Gene Summary
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | ARHGDIB |
| Official Name | Rho GDP dissociation inhibitor beta [Source:HGNC Symbol;Acc:HGNC:679] |
| Ensembl ID | ENSG00000111348 |
| Bio databases IDs | |
| Aliases | Rho GDP dissociation inhibitor beta |
| Synonyms | D4,GDIA2,GDID4,GDIR2,GDP Dissociation Inhibitor,LYGDI,RAP1GN1,Rho GDI 2,RhoGDI beta,RhoGDI β,Rho GDP dissociation inhibitor beta,Rho, GDP dissociation inhibitor beta,Rho GDP dissociation inhibitor β,Rho, GDP dissociation inhibitor β |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- GTPase
- Rho GDP-dissociation inhibitor
- enzyme
- protein binding
- RHO protein GDP dissociation inhibitor
Pathways
Biological processes and signaling networks where the ARHGDIB gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- UFM1
- KCNMA1
- RAC2
- ANKRD1
- CEBPA
- SLC26A6
- FMR1
- CASP3
- VAV1
- GNG8
disease
- Parkinson disease
- prostate cancer
- rheumatoid arthritis
- breast cancer
- hypoplasia
- psoriasis
- dextran sodium sulfate-induced colitis
- peripheral arterial disease
- androgenic alopecia
- chronic sinusitis
regulated by
- butylhydroxybutylnitrosamine
- TNF
- ethanol
- CASP3
- KRAS
- PRKCA
- ITGB2
- tetradecanoylphorbol acetate
- KDM6A
- diethylstilbestrol
regulates
- PTGS2
- reactive oxygen species
- PLC gamma
- RHOA
- CDC42
- PLCB2
- ARHGDIB
- agar
- NFAT (family)
- RAC1
role in cell
- proliferation
- migration
- production in
- growth
- number
- invasion by
- inhibition in
- ubiquitination in
- function
- abnormal quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cytosol
- cytoplasmic vesicles
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ARHGDIB gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- cellular response to redox state
- Rho protein signal transduction
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- membrane
- cytoplasmic vesicle
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- Rho GDP-dissociation inhibitor activity
- GTPase activity
- GTPase activator activity
- small GTPase binding