ACKR4

ACKR4 Gene Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]

Details

Type
Protein Coding
Official Symbol
ACKR4
Official Name
atypical chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:1611]
Ensembl ID
ENSG00000129048
Bio databases IDs NCBI: 51554 Ensembl: ENSG00000129048
Aliases atypical chemokine receptor 4
Synonyms
A630091E18Rik,atypical chemokine receptor 4,CCBP2,CC-CKR-11,CCR10,CCR-11,CCRL1,CCX-CKR,CCX-CKR1,CKR-11,Cmkbrl1,LOC684092,PPR1,VSHK1
Species
Human, homo_sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • Cholecystokinin A receptor, N-terminal
  • chemokine receptor
  • 7 transmembrane receptor (rhodopsin family)
  • protein binding
  • seven-transmembrane G protein-coupled receptor superfamily

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • CCL25
  • SURF6
  • CXCL13
  • vMIP-2
  • CCL7
  • CCL8
  • CCL19
  • CCL21
  • ATP12A
  • CCL2
disease
  • neoplasia
  • atopic dermatitis
  • hyperplasia
  • Hutchinson-Gilford progeria syndrome
  • experimental autoimmune encephalomyelitis
regulated by
  • DNASE2
  • IRF7
  • IRF3
  • podocytes
  • VEGF
  • dexamethasone
  • CCL21
  • CXCL12
  • NPC1
  • triamcinolone acetonide
regulates
  • CCL21
  • chemokine
  • ligand
role in cell
  • activation in
  • proliferation
  • migration
  • quantity
  • number
  • function
  • degradation in
  • abnormal number
  • internalization in
  • chemotaxis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cell surface
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the ACKR4 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • chemotaxis
  • immune response
  • vesicle-mediated transport
  • G-protein coupled receptor signaling pathway
  • chemokine-mediated signaling pathway
  • calcium-mediated signaling
  • elevation of cytosolic calcium ion concentration
  • cell chemotaxis

CELLULAR COMPONENT

Where in the cell the gene product is active
  • early endosome
  • external side of plasma membrane
  • recycling endosome
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • C-C chemokine binding
  • protein binding
  • C-C chemokine receptor activity
  • scavenger receptor activity
  • chemokine receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.