Klhl42 Gene Summary [Mouse]
Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Predicted to be located in cytoplasm and spindle. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in early conceptus; genitourinary system; and olfactory epithelium. Orthologous to human KLHL42 (kelch like family member 42). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl42 |
| Official Name | kelch-like 42 [Source:MGI Symbol;Acc:MGI:2444786] |
| Ensembl ID | ENSMUSG00000040102 |
| Bio databases IDs | |
| Aliases | kelch-like 42 |
| Synonyms | A330079N23Rik, C230080I20Rik, Ctb9, kelch-like 42, kelch like family member 42, kelch-like family, member 42, KIAA1340, KLHDC5, mKIAA1340, RGD1560924 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- ubiquitin-protein transferase activity
- BTB/POZ domain
- enzyme
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-insulin-dependent diabetes mellitus
- Sézary syndrome
- Klinefelter syndrome
- Turner syndrome
- diabetes mellitus
regulated by
- bleomycin
- Tgfb
role in cell
- production in
- phosphorylation in
- ubiquitination in
- formation
- formation in
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- spindle pole
- spindle fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl42 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- regulation of microtubule-based process
Cellular Component
Where in the cell the gene product is active
- spindle
- cytosol
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding