Klk10 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human KLK10 (kallikrein related peptidase 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klk10 |
| Official Name | kallikrein related-peptidase 10 [Source:RGD Symbol;Acc:1303242] |
| Ensembl ID | ENSRNOG00000030281 |
| Bio databases IDs | |
| Aliases | kallikrein related-peptidase 10 |
| Synonyms | 2300002A13RIK, AC011473.4, KALLIKREIN 10, kallikrein related-peptidase 10, Klnj, NES1, PRRSL1, PRSSL1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klk10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
Pathways
Biological processes and signaling networks where the Klk10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- serous ovarian adenocarcinoma
- serous ovarian cancer
- uterine serous papillary cancer
- organismal death
- psoriasis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- atopic dermatitis
- atherosclerosis
role in cell
- expression in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klk10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type peptidase activity
- serine-type endopeptidase activity