Target List
Acute Rejection - Innate Immunity
Pattern Recognition Receptors (PRRs)
TLR3, TLR4, TLR9
Cytokines
CCL11 (Eotaxin), CCL2 (MCP-1), CCL4 (MIP-1B), CCL5 (RANTES), CSF2 (GM-CSF), CXCL10 (INP10), CXCL8 (IL8), IFNG, IL10, IL12A, IL13, IL16, IL1B, IL2, IL2RA (CD25), IL3, IL32, IL4, IL5, IL6, TNF
Other Innate Immunity Genes
ADAM17 (CD156B), C3, CASP1 (ICE), CASP3, CASP8 (FLICE), CCR2, CCR3, CD14, CD28, CD8A, FAS, FASLG (TNFSF6), FCGR1A, GZMA, GZMB, MS4A1, NFKB1, NOS2 (iNOS), PRF1, PSMB9, STAT1, STAT6, TAP1 (ABCB2), TNFAIP3, TNFSF10 (TRAIL)
Acute Rejection - Adaptive Immunity
Th1 Markers & Immune Response
CCR5, CCR7, CD80, CTLA4, CXCR3, IFNG, STAT4
Th2 Markers & Immune Response
CD86, IL10, IL13, IL4, IL5, IL6
T-Cell Activation
CD80, CD86, ICAM1, IFNG
Cytokines
CCL2 (MCP-1), CCL4 (MIP-1B), CCL5 (RANTES), CSF2 (GM-CSF), CXCL10 (INP10), IFNG, IL10, IL13, IL4, IL5, IL6, TNF
Leukocyte Recruitment
CD40 (TNFRSF5), CD40LG, ICAM1, THBS1 (TSP-1), VCAM1
Chronic Rejection
Pro-Fibrotic
CCL3 (MIP-1A), CCN2, IL13, IL4, IL5
Anti-Fibrotic
BMP7, COL1A2, IFNG, IL10, THBS2
Cell Adhesion Molecules
ICAM1, ITGA2, ITGAE, ITGAM, VCAM1
Cellular Infiltration
BMP7, CCR2, CD44, COL1A2, CX3CR1, CXCL11 (I-TAC, IP-9), CXCL9 (MIG), CXCR4, MMP1, MMP2, MMP7, MMP9, PECAM1, TGFB1, TGFB2, TGFB3, THBS2, TIMP1, VEGFA