Coagulation is a complex process that responds to injury by the rapid formation of a clot. Coagulation can be initiated via the extrinsic or intrinsic pathways. The extrinsic pathway begins when an injury exposes platelets to collagen in the vessel wall and plasma factor VIIa (FVIIa) to extravascular tissue factor (TF). Platelets aggregate at the site of injury to form the primary hemostatic clot. TF binds FVIIa and accelerates the activation of FXa...