Signaling through the LT-βR pathway is a crucial element in the maintenance of this organized microenvironment. It plays important roles in embryonic development and organization of secondary lymphoid tissues and maintenance of their architecture in adults. It binds to specific ligands, such as: LT-α1β2 ; and homotrimmer LIGHT, a recently identified member of TNF superfamily; and the lymphotoxin LT-β. LT-βR activates multiple signaling pathways including transcriptional factor NF-κB , and cell death.The LT-α1β2-LT-βR system is required for the formation of lymphoid tissue as well as the segregation of T- and B-lymphocytes into distinct compartments in the spleen and the formation of germinal centers, which is accomplished by the expression of adhesion molecules and Chemokines...