Nitric Oxide (NO) is formed endogenously by a family of enzymes known as NO synthases (NOS). Three distinct isoforms of NOS have been identified: nNOS being the isoform first found in neuronal tissue, iNOS which is inducible in a wide range of cells and tissues, and eNOS, which was first characterized in vascular endothelial cells. nNOS plays several important roles in the brain including regulation of synaptic signaling and plasticity. Additionally, high levels of nNOS protein are present in skeletal muscle where NO controls muscle contractility and local blood flow .NO is generated via a five-electron oxidation of a terminal guanidine nitrogen on L-Arginine by nNOS...