Target List
Glucocorticoid Receptor & Cotranscription Factors
ATF4, CEBPA, CEBPB, CREB1, CREB3, CREB3L4, NR3C1 (GRL), POU2F1, POU2F2, STAT5A, STAT5B
Glucocorticoid Receptor Target Genes
Glucose & Fatty Acid Metabolism
ASPH, GDPD1, GLUL, GOT1, H6PD, PDP1
Cytokines & Chemokines
EDN1, IL10, IL1RN, IL6, IL6R, TNF
Growth Factors
ANGPTL4, CCN2
Extracellular Matrix (ECM) Molecules
COL4A2, HAS2, LOX
Cytoskeleton Regulators
PLEKHF1, RHOB, RHOJ, SNTA1
Endocytosis & Exocytosis
ANXA4, EHD3, MERTK, PLEKHF1
Cell Surface Receptors
CALCR, GHRHR, PDGFRB, VLDLR
Channels & Transporters
AQP1, SLC10A6, SLC19A2, SLC22A5
Signal Transduction
BMPER, DIRAS2, DUSP1 (PTPN16), NFKBIA (IκBα, MAD3), PIK3R1 (p85-ALPHA), PLD1, RASA3, RGS2, SESN1, SGK1, SPHK1, TNF, USP2
Stress Responses
BCL6, DDIT4 (REDD1), PDCD7, SESN1, SGK1
Transcription Factors
ARID5B, CEBPB, FOSL2, KLF13, KLF9, NFKBIA (IκBα, MAD3), TBL1XR1, TNFAIP3, TSC22D3, VDR, ZFP36, ZHX3
Circadian Rhythm
PER1, PER2
RNA Processing
ADARB1, AFF1, HNRNPLL
Protein Folding & Trafficking
FKBP5, LOX
Metallothioneins
MT1E, MT2A
Nucleotide Metabolism
AK2, AMPD3, XDH
Other Glucocorticoid Receptor Target Genes
CYB561, ERRFI1, SPSB1, USP54, ZNF281
Up-Regulated in Adipose & Muscle Tissue
ADARB1, AFF1, AMPD3, ANXA4, ARID5B, ASPH, BMPER, DDIT4 (REDD1), DUSP1 (PTPN16), EHD3, ERRFI1, FKBP5, GDPD1, GLUL, H6PD, HNRNPLL, KLF13, LOX, MERTK, PDP1, PER1, PER2, PIK3R1 (p85-ALPHA), PLD1, PLEKHF1, RASA3, RGS2, RHOJ, SESN1, SGK1, SLC10A6, SNTA1, SPHK1, SPSB1, TBL1XR1, TSC22D3, USP2, USP54, VDR, VLDLR, XDH, ZFP36, ZHX3
Up-Regulated in Muscle Tissue
CCN2, CEBPB, COL4A2, CYB561, DIRAS2, EDN1, KLF9
Up-Regulated in Adipose Tissue
ANGPTL4, BCL6, FOSL2, NFKBIA (IκBα, MAD3), RHOB, SLC19A2, SLC22A5, TNFAIP3
Down-Regulated in Adipose Tissue
AK2, DIRAS2, HAS2, PDGFRB