Support
icon_0328_cc_gen_hmr_bacteria-s

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

The innate immune system uses a variety of pattern-recognition receptors (PRRs) that recognize conserved microbial structures or pathogen-associated molecular patterns, such as those that occur in the bacterial cell-wall components peptidoglycan and lipopolysaccharide. PPRs are classified as:1)Membrane bound PRRs: These are referred to as toll-like receptors (TLRs). Eleven such receptors have been identified in mammals. TLRs are transmembrane receptors which use adapter proteins like TRAF6 and Myd88 to initate NF-κB and other signaling pathways that induce pro-inflammatory cytokines. 2)Extracellular PRRs: These include the complement proteins, pentraxins and collectins...

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

Pathway Summary

The innate immune system uses a variety of pattern-recognition receptors (PRRs) that recognize conserved microbial structures or pathogen-associated molecular patterns, such as those that occur in the bacterial cell-wall components peptidoglycan and lipopolysaccharide. PPRs are classified as:1)Membrane bound PRRs: These are referred to as toll-like receptors (TLRs). Eleven such receptors have been identified in mammals. TLRs are transmembrane receptors which use adapter proteins like TRAF6 and Myd88 to initate NF-κB and other signaling pathways that induce pro-inflammatory cytokines. 2)Extracellular PRRs: These include the complement proteins, pentraxins and collectins. These molecules respond to bacterial and viral triggers through the process of opsonization, phagocytosis and apoptosis. 3)Cytoplasmic PRRs: These include the NODs, NALPs and PKRs. NODs for example react to peptidoglycans by activating NF-κ, therefore inducing the production of pro-inflammatory cytokines. PKRs react by inhibiting translation as well as inducing proinflammatory cytokines.

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses Genes list

Explore Genes related to Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

Products related to Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

Explore products related to Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
GeneGlobe ID: PAHS-018Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Toll-Like Receptor Signaling Pathway
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-097Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Inflammasomes
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: UPHS-097Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Inflammasomes
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-018Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Toll-Like Receptor Signaling Pathway
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-097Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Inflammasomes
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-018Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Toll-Like Receptor Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.