Target List
Alveolar Soft Part Sarcomas
APC, CDH1 (E-Cadherin), KMT2D, NTRK3, PTEN, TP53 (p53), ASPSCR1, TFE3
Angiosarcomas & Epitheliod Haemangioendotheliomas
AKT1, ALK, APC, AR, ARID1A, ARID1B, ARID2, ASXL1, ATM, ATR, ATRX, BRAF, BRCA1, BRCA2, CASP8 (FLICE), CDKN2A (P16INK4A), CIC, CREBBP (CBP), CSMD3, CTNNB1, DCC, EGFR (ERBB1), EP300, EPHA3, EPHA7, ERBB2 (HER-2, NEU), ERBB3, ERBB4, EZH2, FAT1, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FLT4 (VEGFR2), HRAS, JAK3, KDM6A, KDR (VEGFR3), KMT2D, KRAS, LRP1B, MED12, MET, MLH1, MPL, MSH2, MTOR, MUC16, NBEA, NCOR1, NF1, NOTCH2, NRAS, NSD1, NTRK3, PAX5, PBRM1, PDGFRB, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), PLCG1, PRDM1, PREX2, PTCH1, PTEN, PTPRB, PTPRD, PTPRT, ROS1, SETD2, SMARCD1, TERT, TGFBR2, TP53 (p53), TRAF7, TRRAP, TSC1, TSC2, ZFHX3, CAMTA1, CEP85L, CIC, LEUTX, ROS1, TFE3, YAP1
Chondrosarcomas
AKAP9, ALK, AR, ARID1A, ATRX, CACNA1D, CAMTA1, CDKN2A (P16INK4A), CNTNAP2, COL2A1, DNMT3A, EED, EPHA3, EPHA7, ERBB3, ERBB4, FLT4 (VEGFR2), H3-3A, HRAS, IDH1, IDH2, IRS4, JAK1, KDM6A, KDR (VEGFR3), KMT2D, LRP1B, MLLT3, MUC16, MUTYH, MYH9, NF2, NRAS, PALB2, POLE, PTCH1, PTEN, PTPRB, PTPRT, RB1, ROS1, SDHA, SETD2, SMAD2 (MADH2), SMARCB1, SUFU, TERT, TET2, TP53 (p53), TSC1, ZFHX3, ACVR2A, CDX1, EWSR1, FN1, HEY1, IRF2BP2, NCOA2, NR4A3 (NOR1), TAF15, TCF12, TFG
Chordomas
ALK, APC, AR, ARID1A, ATM, CBL, CDKN2A (P16INK4A), CTNNB1, KDR (VEGFR3), KIT (CD117), KMT2A, KMT2D, NRAS, PIK3CA (p110-alpha), PTEN, SETD2, SMARCB1, TP53 (p53)
Clear Cell Sarcomas
BRAF, CDKN2A (P16INK4A), EGFR (ERBB1), NRAS, PTEN, TP53 (p53), ATF1, CREB1, EWSR1, FLI1, NUTM2B, YWHAE
Dermatofibrosarcoma Protuberans
FGFR1, MED12, NF1, TGFBR2, COL1A1, PDGFB
Desmoplastic Small Round Cell Tumors
APC, CIC, CREBBP (CBP), DAXX, EGFR (ERBB1), EP300, EPHA3, KMT2C, MTOR, ROS1, SMARCA4, TET2, ERG, EWSR1, FLI1, PATZ1, WT1
Endometrial Stromal Sarcomas
ASXL1, CTNNB1, DCC, ERBB3, FBXW7, FGFR2, FLT3, KMT2C, KRAS, MED12, PIK3CA (p110-alpha), PTCH1, TP53 (p53), ALK, BCOR, CXorf67, EPC1, FN1, JAZF1, MBTD1, MEAF6, NUTM2A, NUTM2B, PHF1, SUZ12, YWHAE, ZC3H7B
Epithelioid Sarcomas
DICER1, SMARCB1, TET2, TGFBR2, CREB3L1, CREB3L2, EWSR1, FUS, KLF17, SS18, SSX1
Ewing Sarcomas
AFF3, AKAP9, ALK, APC, AR, ARID1A, ARID1B, ARID2, ASXL1, ATM, ATR, ATRX, BCOR, BIRC6, BRAF, BRCA1, BRCA2, CACNA1D, CAMTA1, CARD11, CBL, CD209, CD79B, CDH1 (E-Cadherin), CDKN2A (P16INK4A), CHD4, CIC, CLTCL1, COL2A1, COL3A1, CREBBP (CBP), CSMD3, CTNNB1, DAXX, DCC, DDX10, DGCR8, DICER1, DNMT3A, EED, EGFR (ERBB1), EP300, EPHA3, EPHA7, EPS15, ERBB2 (HER-2, NEU), ERBB4, ERCC5, EZH2, FAM131B, FAM47C, FANCA, FAT1, FAT4, FBXW7, FGFR1, FGFR3, FGFR4, FLNA, FLT4 (VEGFR2), GNAS, GRIN2A, HNF1A, HRAS, IDH1, IDH2, IRS4, KDR (VEGFR3), KIT (CD117), KMT2A, KMT2C, KMT2D, KRAS, LRP1B, MAML2, MED12, MET, MLH1, MLLT3, MSH2, MTOR, MUC16, MUC4, MUTYH, MYH9, MYOD1, NCOR1, NCOR2, NF1, NF2, NOTCH1, NOTCH2, NPM1, NRAS, NSD1, NTRK3, PALB2, PAX5, PBRM1, PDGFRB, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), PLCG1, PML, POLE, PRDM1, PRDM2 (RIZ1), PREX2, PTCH1, PTEN, PTPN13, PTPRB, PTPRD, PTPRT, RB1, RECQL4, ROS1, SDHA, SETD2, SMARCA4, SMARCB1, SPEN, STAG2, SUFU, TERT, TET2, TNC, TOP1, TP53 (p53), TRAF7, TRRAP, TSC1, TSC2, XPC, ZFHX3
Fibrosarcomas
ATRX, BCOR, BRCA1, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), EZH2, FGFR3, FLT3, FOXP1, KDM6A, KDR (VEGFR3), KIT (CD117), KRAS, NF1, NF2, NRAS, POLE, PTEN, RB1, TERT, TP53 (p53), TRAF7, BRAF, COL1A1, CREB3L1, CREB3L2, EWSR1, FUS, LMNA, NTRK1, PDGFB, TOM1L2
Gastrointestinal Stromal Tumors (GIST)
ALK, APC, AR, ARID1A, ARID1B, ARID2, ASXL1, ATR, ATRX, BRAF, BRCA2, CARD11, CBL, CDH1 (E-Cadherin), CDKN2A (P16INK4A), CHD4, CREBBP (CBP), DAXX, DICER1, EGFR (ERBB1), EP300, EPHA7, ERBB4, FAT1, FBXW7, FGFR1, FLT4 (VEGFR2), FOXP1, H3-3A, HNF1A, JAK1, KDM6A, KDR (VEGFR3), KIT (CD117), KMT2A, KMT2C, KMT2D, KRAS, MED12, MSH2, MTOR, MYOD1, NF1, NF2, NOTCH1, NOTCH2, PBRM1, PDGFRA, PDGFRB, PIK3CA (p110-alpha), POLE, PTCH1, PTEN, PTPRT, RB1, RECQL4, ROS1, SDHA, SETD2, SH2B3, SPEN, TERT, TET2, TGFBR2, TP53 (p53), TRAF7, TSC1, TSC2, ZFHX3
Kaposi Sarcomas
BRAF, PIK3CA (p110-alpha), TP53 (p53)
Leiomyosarcomas
ALK, APC, AR, ARID1A, ARID1B, ARID2, ASXL1, ATM, ATR, ATRX, BRCA1, BRCA2, BRD4, CARD11, CBL, CDH1 (E-Cadherin), CREBBP (CBP), DAXX, DNMT3A, EED, EP300, EPHA3, ERBB3, ERBB4, ERCC5, EZH2, FGFR1, FGFR3, FOXP1, GRIN2A, JAK1, JAK3, KDM6A, MET, MPL, MSH2, NCOR1, NF2, NPM1, PAX5, RECQL4, TGFBR2, TOP1, TRAF7, EWSR1, PBX3, WT1
Liposarcomas
AKT1, ALK, APC, ARID1A, ARID1B, ATM, ATRX, BRAF, BRCA2, BRD4, CBL, CD79B, CDH1 (E-Cadherin), CDKN2A (P16INK4A), CIC, COL3A1, CTNNB1, DICER1, DNMT3A, EGFR (ERBB1), EP300, ERBB2 (HER-2, NEU), ERBB4, FAT1, FAT4, FBXW7, FGFR1, FGFR2, FGFR3, FOXP1, HRAS, JAK1, JAK3, KDM6A, KDR (VEGFR3), KIT (CD117), KMT2A, KMT2C, KMT2D, KRAS, MAML2, MLH1, MPL, MUTYH, NCOR1, NF1, NF2, NOTCH2, NSD1, PBRM1, PDGFRA, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), POLE, PRDM1, PTEN, RB1, RECQL4, ROS1, SDHA, SETD2, SMARCA4, TERT, TET2, TP53 (p53), TSC1, ZFHX3, DDIT3 (GADD153, CHOP), EWSR1, FUS, LGR5, NUP107
Malignant Peripheral Nerve Sheath Tumors (MPNST)
ARID2, BCOR, BIRC6, BRAF, BRCA1, CBL, CDKN2A (P16INK4A), EED, FAT1, KRAS, NF1, NRAS, PAX5, PDGFRA, STAG2, TERT, TP53 (p53)
Osteosarcomas
AKT1, ALK, APC, AR, ARID1A, ASXL1, ATR, ATRX, BCOR, BRAF, BRCA1, BRCA2, BRD4, CACNA1D, CAMTA1, CARD11, CBL, CD209, CDH1 (E-Cadherin), CDKN2A (P16INK4A), CHD4, CLTCL1, COL2A1, CREBBP (CBP), CSMD3, DAXX, DCC, DDX10, DNMT3A, EGFR (ERBB1), EP300, EPHA7, ERBB4, FAM47C, FANCA, FAT4, FBXW7, FGFR3, FGFR4, FLNA, FLT3, FOXP1, GNAS, GRIN2A, H3-3A, IDH2, JAK1, JAK3, KDR (VEGFR3), KMT2A, KMT2C, KMT2D, LRP1B, MED12, MET, MLH1, MLLT3, MUC16, MUC4, NBEA, NCOR1, NCOR2, NF1, NF2, NOTCH2, NPM1, NTRK3, PAX3, PBRM1, PDGFRB, PIK3CA (p110-alpha), PIK3CB, PIK3R1 (p85-ALPHA), POLE, PRDM1, PRDM2 (RIZ1), PREX2, PTCH1, PTEN, PTPRD, PTPRT, RB1, RECQL4, ROBO2, ROS1, SDHA, SETD2, SMAD2 (MADH2), SMARCA4, SPEN, STAG2, SUFU, TERT, TET2, TGFBR2, TNC, TP53 (p53), TRRAP, TSC1, TSC2, WNK2, XPC, ZFHX3
Perivascular Epithelioid Cell Tumors (PEComa)
ALK, ATM, ATRX, CIC, JAK3, KDM6A, MED12, NOTCH2, NTRK3, RB1, SDHA, TP53 (p53), TSC1, TSC2, DVL2, SFPQ, TFE3
Pleomorphic Sarcomas (Malignant Fibrous Histiocytoma)
ALK, APC, AR, ARID1A, ARID1B, ARID2, ASXL1, ATM, ATR, ATRX, BRAF, BRCA1, BRCA2, BRD4, CARD11, CASP8 (FLICE), CD79B, CDKN2A (P16INK4A), CIC, CTNNB1, DICER1, DNMT3A, EGFR (ERBB1), EP300, EPHA3, ERBB2 (HER-2, NEU), ERBB3, ERBB4, EZH2, FANCA, FAT1, FBXW7, FGFR1, FGFR4, FLT3, FOXP1, GRIN2A, HRAS, IDH1, JAK1, JAK3, KIT (CD117), KMT2A, KMT2C, KMT2D, KRAS, MET, MLH1, MSH2, MTOR, MUTYH, MYOD1, NCOR1, NF1, NF2, NOTCH1, NOTCH2, NPM1, NRAS, NSD1, NTRK3, PALB2, PAX5, PBRM1, PDGFRB, PIK3CA (p110-alpha), POLE, PRDM1, PTCH1, PTEN, PTPN11, PTPRD, PTPRT, RB1, ROS1, SETD2, SMARCA4, SMARCB1, SUFU, TERT, TET2, TGFBR2, TOP1, TP53 (p53), TRAF7, TSC2, ZFHX3, CITED2, MED12, PRDM10
Rhabdoid Tumors
CREBBP (CBP), KDM6A, KMT2C, MUC16, PBRM1, SETD2, SMARCA4, SMARCB1, TSC2, NCOA4, RET
Rhabdomyosarcomas
AFF3, AKAP9, ALK, APC, AR, ARID1A, ARID1B, ARID2, ASXL1, ATM, ATR, ATRX, BCOR, BRAF, BRCA1, BRCA2, CASP8 (FLICE), CDKN2A (P16INK4A), CHD4, CIC, CLTCL1, CNTNAP2, COL2A1, CREBBP (CBP), CSMD3, CTNNB1, DAXX, DCC, DGCR8, DICER1, DNMT3A, EP300, EPHA3, EPHA7, EPS15, ERBB2 (HER-2, NEU), ERBB3, ERCC4, ERCC5, EZH2, FAM131B, FAM47C, FANCA, FAT1, FAT4, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLT3, FLT4 (VEGFR2), FOXP1, GNAS, GRIN2A, HNF1A, HRAS, IRS4, KDM6A, KDR (VEGFR3), KIT (CD117), KMT2C, KMT2D, KRAS, LRP1B, MAML2, MED12, MET, MLH1, MPL, MSH2, MTOR, MUC16, MUTYH, MYH9, MYOD1, NBEA, NCOR2, NF1, NOTCH1, NOTCH2, NRAS, NSD1, NTRK3, PALB2, PDGFRA, PDGFRB, PIK3CA (p110-alpha), PML, POLE, PRDM1, PRDM2 (RIZ1), PREX2, PTCH1, PTEN, PTPN11, PTPN13, PTPRT, RECQL4, ROBO2, ROS1, SETD2, SFRP4, SH2B3, SMARCA4, SMARCB1, TET2, TNC, TP53 (p53), TRAF7, TRRAP, TSC1, TSC2, WNK2, XPC, ZFHX3, CITED2, EWSR1, FLI1, FOXO1, NCOA1, NCOA2, PAX3, PAX7, SRF, TEAD1, VGLL2
Solitary Fibrous Tumors
ALK, APC, ARID2, CBL, EP300, ERBB4, FAT1, FBXW7, FGFR1, FGFR3, KMT2D, NF1, NSD1, PIK3R1 (p85-ALPHA), PTEN, SPEN, SUFU, TERT, TP53 (p53), NAB2, STAT6
Synovial Sarcomas
ARID1B, ARID2, BCOR, BRAF, CDH1 (E-Cadherin), CTNNB1, EGFR (ERBB1), ERBB4, FGFR1, FLT4 (VEGFR2), HRAS, KDR (VEGFR3), KMT2A, KMT2C, KMT2D, KRAS, MED12, MLH1, PALB2, PDGFRA, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PRDM1, PTEN, SETD2, TERT, TP53 (p53), TRAF7, TRRAP, ZFHX3, COL6A3, CSF1 (MCSF), S100A10, SS18, SS18L1, SSX1, SSX2, SSX4
Undifferentiated; Unclassified or Other Sarcomas
ARID2, ATM, ATRX, BRCA2, CIC, CREBBP (CBP), CTNNB1, DICER1, EED, EGFR (ERBB1), EPHA7, FBXW7, FLT3, FOXP1, H3-3A, HNF1A, KDM6A, MED12, MET, NCOR1, NOTCH2, NSD1, PALB2, PBRM1, PTCH1, PTPRD, ROS1, SH2B3, SPEN, STAG2, SUFU, TP53 (p53), ATF1, BCOR, CCNB3, CREM, ERG, ETV4, EWSR1, FGF1, FGFR1, FLI1, FN1, FOXO1, FUS, JAZF1, MAML3, PAX3, POU5F1 (OCT4), RUNX1 (AML1), RUNX1T1, SUZ12
Askins Tumors
ERG, EWSR1, FLI1, FUS
Chondrosarcomas; Myxoid
NR4A3 (NOR1), TAF15
Congenital (Infantile) Fibrosarcomas
ETV6, MET, NTRK3, TFG
Ewing's Sarcomas
CIC, ERG, ETV1, ETV4, EWSR1, FEV, FLI1, FOXO4, FUS, NFATC2, SMARCA5, SP3
Myofibroblastic Sarcomas
ALK, LMNA, NTRK1, RELA, ROS1, SRF, TFG, TPM3, YWHAE
Other Sarcomas
ALK, ASPSCR1, COL1A1, DDIT3 (GADD153, CHOP), ETV6, EWSR1, FOXO1, FUS, GLI1, HMGA2, LMNA, MKL2, NPM1, NTRK1, NTRK3, PAX3, PAX7, PDGFB, PLAG1, SS18, SSX1, SSX2, TFE3, USP6, WT1