Target List
Necrosis
Regulation of Necrosis
FAS (TNFRSF6)FASLG (TNFSF6)RIPK1SLC25A4TNF
TNF-Induced Necrosis
ATP6V1G2CYLDDPYSL4EIF5BFOXI1GALNT5TMEM57GRB2 (GRB2)LOC704611 (JPH3)BMFDENND4ALOC712324 (COMMD4)HSPBAP1CCDC103MAGPARP2PVRRAB25DEFB1SPATA2SYCP2TXNL4B
Other Necrosis Genes
ARCA9CD40 (TNFRSF5)H2AFXRIPK1LOC708606 (FADD)RIPK3LOC721111 (PALM)MPGMGEA5PARP1 (ADPRT1)SP1TMEM123
Potential Necrosis Genes
RIPK1 Interactors
RIPK3NFKB1RIPK2
RIPK3 Interactors
GLUD1GLULRIPK1PYGL
PARP1 Interactors
CAPN1CAPN2CAPN3CAPN7LOC698077 (CAPN5)LOC699341 (CAPNS1)CAPN6
Death Domain Receptors
FAS (TNFRSF6)TNFRSF1A (TNFR1)TNFRSF10A (TRAIL-R)
Death Receptor Signaling
BIRC3 (c-IAP1)CASP8AP2CYLDFAF1FEM1BNGFRAP1LOC698160 (TRADD)LRDDIKBKGTNFSF15RIPK1LOC708606 (FADD)LOC711681 (NGF)MADDMYD88NGFRPARP1 (ADPRT1)TNFRSF14TNFRSF17TNFRSF18TNFRSF19TNFRSF1BTNFRSF25 (DR3)TNFRSF4 (OX40)TNFRSF8TRAF5
Apoptosis
Pro-Apoptotic
AIFM1BNIP3LCASP8AP2FAF1FAS (TNFRSF6)FEM1BNGFRAP1FASLG (TNFSF6)LOC698160 (TRADD)LRDDIKBKGBMFRIPK1LOC708606 (FADD)MADDRIPK3BAXLOC100426120 (BNIP3)NGFRRIPK2TNFRSF10A (TRAIL-R)TNFRSF25 (DR3)TNFRSF8TNFSF10 (TRAIL)TRAF5
Anti-Apoptotic
BIRC3 (c-IAP1)FAS (TNFRSF6)RIPK1LOC711681 (NGF)MYD88NFKB1NGFRRIPK2TNFTNFRSF1A (TNFR1)TNFRSF1BTNFRSF4 (OX40)TRAF5
TNF-Induced Apoptosis
ATP6V1G2CYLDSPATA2SYCP2
Oxidative Stress
AIFM1GLUD1CYBBLOC696748 (CYBA)NOX1NOX4
Mitochondrial Genes
AIFM1BNIP3LGLUD1GLULCYBBLOC696748 (CYBA)RIPK1BAXSLC25A4