Target List
Differentially Methylated Promoters
Abcb1b, Apc, Ar, Cav1, Ccna1, Cdh1 (E-cadherin), Cdkn2a (INK4A, p16, p19ARF), Dab2ip, Dkk3, Dlc1, Ednrb, Gpx3, Gstp1, Mgmt (Agt), Msx1, Ptgs2 (Cox2), Rarb, Rassf1, Rbp1, Sfrp1, Slc5a8, Timp2
Up-Regulated in Prostate Cancer
Arntl (Bmal1), Ect2, Etv1, Hal, Igfbp5, Mto1, Pdpk1, Rbm39, Socs3, Sox4 (QuantiNova Symbol: AABR07027575.1), Supt7l
Down-Regulated in Prostate Cancer
Ccnd2, Cln3, Gca, Igf1, Lgals4, Loxl1, Nexn, Ppp2r1b, Sfrp1, Slc5a8, Tfpi2, Usp5
Metastatic Potential
Creb1, Ints6, Max, Ndrg3, Pes1, Scaf11
Androgen Receptor Signaling
Ar, Cav1, Ccnd1, Daxx, Egfr, Gnrh1, Igf1, Il6, Nfkb1, Nrip1, Pten, Shbg, Tgfb1i1, Timp2, Timp3, Vegfa
AKT & PI3 Kinase Signaling
Akt1, Ar, Bcl2, Ccnd1, Ccnd2, Cdh1 (E-cadherin), Cdkn2a (INK4A, p16, p19ARF), Dab2ip, Egfr, Gnrh1, Igf1, Il6, Mapk1 (Erk2), Nfkb1, Pdpk1, Pten, Timp2, Timp3, Tp53 (p53), Vegfa
PTEN Signaling
Akt1, Egfr, Gnrh1, Igf1, Il6, Mapk1 (Erk2), Pdpk1, Pten, Timp2, Timp3, Tp53 (p53), Vegfa
Apoptosis
Bcl2, Casp3, Cdkn1a (Cip1, Waf1), Cdkn2a (INK4A, p16, p19ARF), Egfr, Etv1, Gnrh1, Igf1, Il6, Mapk1 (Erk2), Nfkb1, Pten, Timp2, Timp3, Tp53 (p53), Vegfa
Cell Cycle
Apc, Bcl2, Casp3, Cav2, Ccna1, Ccnd1, Ccnd2, Cdkn1a (Cip1, Waf1), Cdkn2a (INK4A, p16, p19ARF), Dab2ip, Egfr, Gadd45a, Igf1, Ppp2r1b, Pten, Ptgs2 (Cox2), Rb1, Sfn (14-3-3σ), Tp53 (p53)
Transcription Factors
Ar, Arntl (Bmal1), Cdkn2a (INK4A, p16, p19ARF), Creb1, Daxx, Egr3, Erg, Etv1, Max, Msx1, Nfkb1, Nkx3-1, Nrip1, Rarb, Rbm39, Sox4 (QuantiNova Symbol: AABR07027575.1), Srebf1, Supt7l, Tp53 (p53)
Fatty Acid Metabolism
Acaca, Camkk1, Fasn, Hmgcr, Igf1, Prkab1, Srebf1, Stk11 (Lkb1)
Other Prostate Cancer Genes
Mki67, Ptgs1 (Cox1), Tmprss2