Target List
Oncogenes & Tumor Suppressor Genes
AMFRANAPC10ANAPC11ANAPC13ANAPC4ANAPC5ANAPC7APC2BARD1BIRC3BIRC7BRCA1BTRCCBLCBLBCBLCCBLL1CDC16CDC20CDC23CDC27CDH1 (E-cadherin)CUL7FBXO5FBXW5FBXW7LOC100622859MDM2MDM4RCHY1RFWD2RNF139SIAH1SIAH2SKP2TRAF2TRAF5TRAF6TRAF7VHLXIAP
HECT
HACE1HECTD1HECTD2HECTD3HECW1HERC1HERC2HERC3HERC4HERC5HERC6HUWE1ITCHNEDD4NEDD4LSMURF1SMURF2TRIP12UBE3AUBE3BUBE3CUBR5WWP1
U-Box
NOSIPSTUB1UBE4AUBE4BWDSUB1
UBL
PIAS1PIAS2PIAS4RANBP2RBX1TOPORSUHRF2
Single RING-Finger
BIRC/IAP
BIRC3BIRC7LOC100622859XIAP
BRE1
RNF20RNF40
CBL
CBLCBLBCBLCCBLL1
Deltex
DTX3DTX4RNF146
Goliath
RNF13RNF128RNF130RNF167
Makorin
MKRN1MKRN2
Membrane-Associated Ring Finger Proteins
MARCH1MARCH11MARCH2MARCH3MARCH5MARCH6MARCH7MARCH8
MDM
MDM2MDM4
Mindbomb Homologs
MIB1MIB2
NFX
NFX1NFXL1
PDZRN
LNX1PDZRN3PDZRN4
Pellino
PELI1PELI2
PEX
PEX2PEX12
Polycomb Group Genes
BMI1 (PCGF4)CBX8PCGF2PCGF3PCGF5RING1
Praja
PJA1PJA2RNF115RNF126
RBR
ANKIB1ARIH1ARIH2PARK2RBCK1RNF14RNF144ARNF144BRNF19ARNF19BRNF216RNF31
RC3H
RC3H1RC3H2
RKHD
MEX3AMEX3CMEX3D
Seven in Absentia
SIAH1SIAH2
TRAC-I
RNF114RNF125RNF138RNF166
TRAF
TRAF2TRAF3TRAF4TRAF5TRAF6TRAF7
TRIM / RBCC
LOC100513415LOC100524034LOC733579MID1MID2MURF3PMLRNF135TRIM10TRIM11TRIM13TRIM17TRIM2TRIM21TRIM23TRIM24TRIM25TRIM26TRIM27TRIM28TRIM3TRIM31TRIM32TRIM33TRIM36TRIM37TRIM38TRIM39TRIM4TRIM40TRIM41TRIM44TRIM45TRIM52TRIM55TRIM56TRIM62TRIM63TRIM67TRIM68TRIM71TRIM72TRIM8TRIM9TRIML1
UBR Box
UBR1UBR2UBR3UBR4UBR7
VPS
VPS11VPS18VPS41VPS8
ZNRF
ZNRF1ZNRF2
Other Single RING-Finger Proteins
AMFRATRXBCORBFARBRAPBRCA1CCNB1IP1CDC34CGRRF1CHFRCNOT4DCST1DZIP3FANCLHLTFIRAK1IRF2BPLLOC102167889LONRF1LRSAM1LTN1MALT1MNAT1MAP3K1 (MEKK1)MEX3DMGRN1MSL2MUL1MYCBP2MYLIPNEURL1NHLRC1OSTM1PAX6PHRF1RAD18RBBP6RCHY1RFWD2RNF10RNF103RNF11RNF111RNF113ARNF121RNF123RNF139RNF145RNF150RNF152RNF168RNF170RNF180RNF181RNF187RNF207RNF208RNF212RNF215RNF219RNF220RNF24RNF26RNF34RNF38RNF4RNF41RNF43RNF44RNF5RNF6RNF8RSPRY1SHPRHSYVN1TNFAIP3TOPORSTRAIPTTC3UBCUNKUNKLWHSC1ZER1
Multi-Subunit RING-Finger
SCF Complex
BTRCCCNFCUL1FBXL12FBXL14FBXL15FBXL17FBXL18FBXL2FBXL20FBXL3FBXL4FBXL5FBXO11FBXO17FBXO18FBXO2FBXO21FBXO22FBXO25FBXO3FBXO30FBXO31FBXO32FBXO33FBXO4FBXO43FBXO44FBXO5FBXO6FBXO7FBXO9FBXW11FBXW2FBXW4FBXW5FBXW7FBXW8LMO7RBX1SKP1SKP2TSPAN17
ECV Complex
CUL2FEM1BRBX1TCEB1TCEB2VHLZYG11B
CUL3 Complex
BTBD1BTBD2CUL3DIABLOENC1GANKLHL41KBTBD7KCTD10KEAP1KLHL13KLHL2KLHL20KLHL21KLHL22KLHL24KLHL7KLHL9RBX1RHOBTB1RHOBTB3SPOPTNFAIP1ZBTB16
CUL4 Complex
CRBNCUL4ACUL4BDDA1DDB1DDB2DET1DTLPHIPRBX1RFWD2VPRBP
ECS Complex
ASB1ASB18ASB2 (ASB2)ASB3ASB9CISHCUL5LRRC41RNF7SOCS1SOCS2SOCS3SOCS4SOCS5SOCS6SPSB1SPSB2SPSB4TCEB1TCEB2WSB1
CUL7 Complex
CUL7RBX1SKP1
APC/C
ANAPC10ANAPC11ANAPC13ANAPC2ANAPC4ANAPC5ANAPC7APC2CDC16CDC20CDC23CDC27CDH1 (E-cadherin)
BRCC Complex
BARD1BRCA1BRCA2BRCC3RAD51
KPC Complex
RNF123
Multi-Subunit RING-Finger Cullins & Adaptors
ANAPC11APC2CUL1CUL2CUL3CUL4ACUL4BCUL5CUL7DDB1RBX1RNF7SKP1TCEB1TCEB2