CD1, a conserved family of MHC-like glycoproteins specializes in capturing lipid rather than peptide antigen for presentation to T-lymphocytes. The CD1 family consists of five isoforms which are classified into two groups: Group-I (CD1A, CD1B, CD1C, and CD1E) and Group-II (CD1D). Group-I CD1 proteins present self and bacterial lipids to specific T-cells whereas CD1D displays self lipids including sphingolipids and diacylglycerols. CD1-restricted T-cells contribute to both innate and adaptive immune responses. Group-I molecules present microbial fatty acids, glycolipids, phospholipids and lipopeptide antigens...