Cell adhesion to the extracellular matrix (ECM) initiates signals that regulate important physiological events including cell motility and growth, and most often involve changes in the organization of the actin cytoskeleton. Binding of cells to the ECM via integrin receptors leads to a clustering of integrins at the sites of matrix attachment and subsequent recruitment of structural and signaling molecules to these focal contact regions. Proteins present at the cytoplasmic face of focal adhesions (FA) include cytoskeletal proteins such as vinculin and talin. In addition, numerous signaling proteins with enzymatic activity (e.g...