Tumor Necrosis Factor (TNF) family members play important roles in various physiological and pathological processes, including cell proliferation, differentiation, apoptosis, modulation of immune responses and induction of inflammation. TNF family members act through two receptors, TNFR1 and TNFR2. TNFR1 is expressed by all human tissues and is the major signaling receptor for TNFα. TNFR2 is mostly expressed in immune cells and mediates limited biological responses. The 75-kDa TNFR2 binds both TNFα and TNFβ (LTA)...