icon_0328_cc_gen_hmr_bacteria-s

IL-17A Signaling in Gastric Cells

IL-17A is the founding member of the family of IL-17 ligands which include IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. It is a disulfide-linked homodimeric glycoprotein consisting of 155 amino acids which binds to and activates a heterodimeric transmembrane receptor complex consisting of IL-17RC and IL-17RA subunits. IL-17A is mainly produced by Th17 cells but it is also known to be secreted by a variety of innate immune cells including macrophages, dendritic cells, NK cells and NKT cells. IL-17A has been linked to the pathogenesis of various autoimmune and chronic inflammatory diseases including inflammatory bowel disease (IBD).Studies show that IL-17A plays a complex role in the regulation of cytokines and chemokines in intestinal epithelial cells in IBD...

IL-17A Signaling in Gastric Cells

Pathway Summary

IL-17A is the founding member of the family of IL-17 ligands which include IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. It is a disulfide-linked homodimeric glycoprotein consisting of 155 amino acids which binds to and activates a heterodimeric transmembrane receptor complex consisting of IL-17RC and IL-17RA subunits. IL-17A is mainly produced by Th17 cells but it is also known to be secreted by a variety of innate immune cells including macrophages, dendritic cells, NK cells and NKT cells. IL-17A has been linked to the pathogenesis of various autoimmune and chronic inflammatory diseases including inflammatory bowel disease (IBD).Studies show that IL-17A plays a complex role in the regulation of cytokines and chemokines in intestinal epithelial cells in IBD. While IL-17A synergizes with TNF-α to repress the expression of certain TNF-α induced genes such as CXCL10, CXCL11 and CCL5, it synergizes with TNF-α to increase the expression of certain other TNF-α induced genes such as CCL20, CXCL8 and CXCL1. The latter was accomplished by increasing the stability of the target mRNA. Some of these biological actions of IL-17A are mediated in part by EGFR signaling where IL-17A and TNF-α synergistically promote phosphorylation and activation of EGFR, resulting in downstream activation of ERK signaling. Furthermore, transcriptional repression and mRNA stabilization by IL-17A have been shown to depend on ERK and p38 MAPK activation. This complex gene regulation mediated by IL-17A and TNF-α is key to inhibiting expression of Th1-recruiting chemokines while simultaneously increasing the expression of Th17- and neutrophil-recruiting chemokines.Inflammatory processes are also implicated in gastric cancer development. In this context, the contribution of IL-17A versus IL-17F signaling in gastric adenocarcinoma cells has been studied (PMID: 17644350). IL-17A and IL-17F both induce the expression of IL-8. However, IL-17A is a more potent inducer of IL-8 than IL-17F. Also, while IL-17A can activate c-Jun and NF-κB, IL-17F activates only NF-κB to induce IL-8 expression. Thus, IL-17A and possibly IL-17F may contribute to inflammation-associated cancer.

Products related to IL-17A Signaling in Gastric Cells

Explore products related to IL-17A Signaling in Gastric Cells
GeneGlobe ID: PAHS-021Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Common Cytokines
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: PAHS-150Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Cytokines & Chemokines
RT2 Profiler PCR Array
Product Specification
GeneGlobe ID: UPHS-150Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: UPHS-021Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Common Cytokines
QuantiNova LNA Probe PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-150Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Cytokines & Chemokines
QuantiNova LNA PCR Focus Panel
Product Specification
GeneGlobe ID: SBHS-021Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Common Cytokines
QuantiNova LNA PCR Focus Panel
Product Specification

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.