Adrb3 Gene Summary [Rat]
Enables epinephrine binding activity and norepinephrine binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and eating behavior. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of colitis; congestive heart failure; and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adrb3 |
| Official Name | adrenoceptor beta 3 [Source:RGD Symbol;Acc:2061] |
| Ensembl ID | ENSRNOG00000012674 |
| Bio databases IDs | |
| Aliases | adrenoceptor beta 3 |
| Synonyms | Adrab3, ADRB, adrenergic receptor, beta 3, adrenergic receptor, β 3, adrenoceptor beta 3, adrenoceptor β 3, beta-3 adrenergic receptor, Beta3 adrenoceptor, BETA3AR, β-3 adrenergic receptor, β 3-AR, β(3)AR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adrb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- binding protein
- G-protein-coupled receptor binding
- intracellular domain
- protein homodimerization
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- PXXP motif
- beta3-adrenergic receptor
- seven-transmembrane G protein-coupled receptor superfamily
- beta-adrenergic receptor
Pathways
Biological processes and signaling networks where the Adrb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Cardiac Hypertrophy Signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Gαs Signaling
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- metastatic gastric cancer
- cancer
- infection
- metastasis
- neoplasia
- thyroid gland neoplasm
- Huntington disease
- major depression
- asthma
role in cell
- expression in
- induction in
- production in
- differentiation
- activation
- phosphorylation in
- quantity
- cellular infiltration by
- accumulation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adrb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of multicellular organism growth
- generation of precursor metabolites and energy
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- energy reserve metabolic process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- receptor-mediated endocytosis
- negative regulation of G-protein coupled receptor protein signaling pathway
- diet induced thermogenesis
- vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
- eating behavior
- carbohydrate metabolic process
- brown fat cell differentiation
- response to cold
- heat generation
- adenylate cyclase-activating adrenergic receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- epinephrine binding
- protein homodimerization activity
- protein binding
- beta3-adrenergic receptor activity
- beta-adrenergic receptor activity
- norepinephrine binding
- beta-3 adrenergic receptor binding