DKK1 Gene Summary [Human]
This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
Details
| Type | Protein Coding |
| Official Symbol | DKK1 |
| Official Name | dickkopf WNT signaling pathway inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:2891] |
| Ensembl ID | ENSG00000107984 |
| Bio databases IDs | |
| Aliases | dickkopf WNT signaling pathway inhibitor 1 |
| Synonyms | dickkopf WNT signaling pathway inhibitor 1, mdkk-1, NEWGENE 1307313, SK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DKK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins
- receptor antagonist activity
- protein binding
- low-density lipoprotein receptor binding
- growth factor
- cysteine rich domain
- first cysteine-rich (Cys-1) domain of Dickkopf proteins
Pathways
Biological processes and signaling networks where the DKK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- atherosclerosis
- epithelial cancer
- epithelial neoplasia
- endometriosis
- gastric adenocarcinoma
- gastric epithelial cancer
- papillary renal cell carcinoma
- papillary renal cell neoplasia
role in cell
- cell death
- proliferation
- apoptosis
- replication in
- growth
- signaling in
- number
- expression in
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DKK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart valve development
- endocardial cushion development
- regulation of neuron apoptotic process
- negative regulation of protein binding
- face morphogenesis
- learning or memory
- negative regulation of transcription from RNA polymerase II promoter
- embryonic limb morphogenesis
- response to retinoic acid
- forebrain development
- heart induction
- hair follicle development
- negative regulation of neuron projection development
- negative regulation of peptidyl-serine phosphorylation
- canonical Wnt receptor signaling pathway
- endoderm formation
- mesoderm formation
- regulation of synaptic transmission, glutamatergic
- regulation of receptor internalization
- negative regulation of SMAD protein import into nucleus
- limb development
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- cell morphogenesis
- Wnt receptor signaling pathway involved in somitogenesis
- negative regulation of mesodermal cell fate specification
- regulation of endodermal cell fate specification
- positive regulation of Wnt receptor signaling pathway, calcium modulating pathway
- negative regulation of BMP signaling pathway
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of apoptotic process
- positive regulation of JNK cascade
- positive regulation of gene expression
- negative regulation of cardiac muscle cell differentiation
- negative regulation of Wnt receptor signaling pathway
- negative regulation of ossification
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- low-density lipoprotein particle receptor binding
- protein binding
- receptor antagonist activity