IL1F10 Gene Summary [Human]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL1F10 |
| Official Name | interleukin 1 family member 10 [Source:HGNC Symbol;Acc:HGNC:15552] |
| Ensembl ID | ENSG00000136697 |
| Bio databases IDs | |
| Aliases | interleukin 1 family member 10, FIL1- theta, interleukin-1 receptor antagonist FKSG75 |
| Synonyms | FIL1-theta, FIL1-θ, FKSG75, IL-1HY2, IL1-theta, IL1-θ, IL-38, interleukin 1 family member 10, interleukin 1 family, member 10, Interleukin-38 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL1F10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the IL1F10 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- FXR/RXR Activation
- Graft-versus-Host Disease Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- diarrhea
- weight loss
- experimental autoimmune encephalomyelitis
- DMBA/TPA-induced mouse skin tumorigenesis
- skin neoplasia
- acute myeloid leukemia
- myocardial infarction
- pervasive developmental disorder
- skin squamous cell carcinoma
role in cell
- proliferation
- expression in
- migration
- production in
- phosphorylation in
- cellular infiltration by
- ATP-linked respiration in
- glycolysis in
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL1F10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- inflammatory response to antigenic stimulus
- cytokine-mediated signaling pathway
- positive regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- interleukin-1 receptor binding