Antisense LNA GapmeRs
For highly effective knockdown of mRNA and lncRNA using LNA-enhanced antisense oligonucleotides
- Function by RNase H-dependent degradation of complementary RNA targets
- Provide strand-specific knockdown with no RISC-associated off-target activity
- Active in vivo and in vitro, enabling the analysis RNA function in a wide range of model systems
- Excellent alternative to siRNA for knockdown of mRNA and lncRNA
- Taken up by cells without need for transfection reagents
- Variety of controls support transfection or unassisted uptake protocol optimization