Fibroblast growth factor receptor (FGFR) belongs to the family of receptor tyrosine kinases (RTKs). Binding of fibroblast growth factor (FGF) to its receptor induces receptor dimerization and tyrosine phosphorylation. The phosphorylated form of the receptor is now capable of initiating several signal transducing pathways depending of cell specificity.FGFR phosphorylation causes the tyrosine phosphorylation of SNT1 which leads to GRB2-mediated complex formation with docking protein GAB and nucleotide exchange factor SOS. These key events then lead to the activation of one of several pathways: the Ras/Raf/MEK/ERK pathway, the Rac1/MEKK/p38MAPK pathway or the PI3K/AKT pathway...