Target List
Hedgehog Signaling
Hedgehog Ligands & Regulators
BOC, CDON, DHH, GAS1, HHIP, IHH, SHH
Hedgehog Receptors & Cofactors
DISP3, LRP2, PTCH1, PTCH2, PTCHD1, PTCHD3, RAB23, SMO
Transcription Factors & Regulators
BTRC (bTrCP), CSNK1A1, CSNK1E, FBXW11, GLI1, GLI2, GLI3, GSK3B, PRKACA, PRKACB, STK36, SUFU, ZIC1, ZIC2 (HPE5)
Other Hedgehog Signaling Genes
DISP1, DISP2, FGF9, FKBP8, HHAT, IFT52, KCTD11, NPC1, OTX2
Hedgehog Signaling Target Genes
BCL2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8B, MTSS1, PTCH1, PTCH2, VEGFA, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B
Pathways Crosstalking with Hedgehog Signaling
TGFβ / BMP Signaling
BMP2, BMP4, BMP5, BMP6, BMP7, BMP8B, GREM1, SFRP1
WNT Signaling
BTRC (bTrCP), CTNNB1, FBXW11, FGF9, GSK3B, LATS1, LATS2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B
Hippo Signaling
FAT4, FRMD6, LATS1, LATS2, MOB1B, NF2, STK3
Other Hedgehog Signaling Genes
ERBB4, FGFR3, FOXE1, MAPK1 (ERK2), NUMB, RUNX2, TP53 (p53)