TP53
TP53 Gene Summary
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | TP53 |
| Official Name | tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] |
| Ensembl ID | ENSG00000141510 |
| Bio databases IDs | |
| Aliases | tumor protein p53, Li-Fraumeni syndrome |
| Synonyms | bbl,BCC7,bfy,bhy,BMFS5,LFS1,LFS3,p44,P53,P53 cellular tumour antigen,p53 tumor suppressor,transformation related protein 53,TRP53,tumor protein p53,tumour protein p53 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone deacetylase regulator
- C-terminal regulatory domain
- A/B region
- protein binding activity, bridging
- P53 DNA-binding domain
- transcription factor binding
- core domain, functional
- identical protein binding
- PML binding domain
- HPV-16 E2 protein binding domain
- Transactivation domain 2
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- receptor tyrosine kinase binding
- proline and tyrosine-rich region
- serine phosphorylation site
- chaperone binding
- basic domain
- core domain, structural
- ubiquitin protein ligase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- TAD2 subdomain
- AD1 domain
- nuclear export signal
- loop-sheet-helix domain
- DNA binding domain
- protease binding
- nucleic acid binding
- protein phosphatase binding
- TBP binding domain
- BOX-V domain
- p53 core domain
- protein binding
- sequence-specific DNA binding
- polyproline motif
- acidic domain
- TAD1 subdomain
- Mdm2 protein binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- N-terminal transactivation domain
- mRNA 3' UTR binding
- minimal transactivation domain
- ATM phosphorylation site
- C-terminal oligomerization domain
- transcription factor activity
- extreme C-terminal domain
- protein heterodimerization
- transcription regulator
- LXXLL motif
- P53 transactivation motif
- regulatory domain
- homo-oligomerization domain
- transcription activation domain
- chromatin binding
- cytoplasmic sequestration domain
- Jnk-binding domain
- enzyme
- proline rich domain
- Sh3 domain binding motif
- docking domain
- copper ion binding
- Box I domain
- zinc ion binding
- ion channel binding
- Casein Kinase 2 beta binding domain
- AD2 domain
- sequence-specific DNA binding domain
- lysine rich domain
- acetylation site
- tetramerization domain
- oligomerization domain
- BRCA1-binding domain
- P53 tetramerization motif
- negative regulatory domain
- nuclear localization sequence
- enzyme binding
- histone deacetylase binding
- isomerase
- protein domain specific binding
- central domain
- p53 binding
- DNA dependent ATPase
- activation domain AD1
- S100B binding domain
- DNA binding
- phosphorylation site
- beta strand or sheet
- p300/cbp binding domain
- transcription repression domain
- binding protein
- single-stranded DNA binding
- double-stranded DNA binding
- replication protein A binding domain
- NDB domain
- zinc finger domain
- PXXP motif
Pathways
Biological processes and signaling networks where the TP53 gene plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Aryl Hydrocarbon Receptor Signaling
- ATM Signaling
- Basal Cell Carcinoma Signaling
- Bladder Cancer Signaling
- DNA damage-induced 14-3-3σ Signaling
- HER-2 Signaling in Breast Cancer
- Induction of Apoptosis by HIV1
- Inhibition of Angiogenesis by TSP1
- MIF Regulation of Innate Immunity
- Mouse Embryonic Stem Cell Pluripotency
- Myc Mediated Apoptosis Signaling
- Non-Small Cell Lung Cancer Signaling
- PEDF Signaling
- Polyamine Regulation in Colon Cancer
- Prostate Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
- Role of p14/p19ARF in Tumor Suppression
- Small Cell Lung Cancer Signaling
- Thyroid Cancer Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NR1I2
- FURIN
- CHEK1
- TP53
- ESR1
- BECN1
- ING4
- AHR
- RPA3
- GADD45A
disease
- COVID-19
- non-small cell lung cancer
- metastatic breast cancer
- plasma cell myeloma
- metastasis
- lung cancer
- breast cancer
- secondary neoplasm
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
regulated by
- eicosapentaenoic acid
- CD1D
- FUT2
- SOD1
- NADPH
- gemcitabine
- AICDA
- MYC
- NINJ2
- 1,1,3,3-tetramethylguanidine
regulates
- CASP3
- D-glucose
- superoxide
- palmitic acid
- LMNA
- IL6
- TNF
- PMAIP1
- TP53
- SELE
role in cell
- replication in
- expression in
- activation
- binding
- adhesion
- binding in
- colony formation
- cell death
- survival
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- aggresome
- perinuclear body
- cytoskeleton
- Cytoplasm
- intracellular space
- perinuclear region
- Plasma Membrane
- centrosome
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- cytoplasmic particles
- cytoplasmic aggregates
- metaphase plate
- cytosol
- mitochondria-associated membranes
- mitochondrial matrix
- nuclear foci
- perinucleolar compartments
- nucleoplasm
- perinuclear space
- nucleoli
- nuclear bodies
- nuclear speckles
- nuclear matrix
- mitoplasts
- DNA replication foci
- PML nuclear bodies
- mitotic spindle
- chromatin
- replication fork
- perikaryon
- plasma
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TP53 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- mitochondrial DNA repair
- determination of adult lifespan
- protein localization
- nucleotide-excision repair
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- T cell lineage commitment
- circadian behavior
- hemopoietic progenitor cell differentiation
- oligodendrocyte apoptotic process
- cellular response to UV-C
- neuroblast proliferation
- negative regulation of neuroblast proliferation
- negative regulation of transcription, DNA-dependent
- cardiac muscle cell apoptotic process
- in utero embryonic development
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- regulation of tissue remodeling
- neuron apoptotic process
- regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of mitochondrial membrane permeability
- positive regulation of gene expression, epigenetic
- macromolecular complex assembly
- cerebellum development
- Ras protein signal transduction
- response to DNA damage stimulus
- cellular response to glucose starvation
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
- cellular response to gamma radiation
- negative regulation of stem cell proliferation
- signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of helicase activity
- protein import into nucleus
- signal transduction by p53 class mediator
- release of cytochrome c from mitochondria
- positive regulation of cardiac muscle cell apoptotic process
- multicellular organism growth
- response to salt stress
- replicative senescence
- negative regulation of cell proliferation
- cellular senescence
- intrinsic apoptotic signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of neuron apoptotic process
- bone marrow development
- double-strand break repair
- fibroblast proliferation
- negative regulation of fibroblast proliferation
- protein tetramerization
- stem cell proliferation
- positive regulation of cellular senescence
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of reactive oxygen species metabolic process
- negative regulation of reactive oxygen species metabolic process
- negative regulation of glial cell proliferation
- T cell differentiation in thymus
- mitotic cell cycle G1/S transition DNA damage checkpoint
- positive regulation of release of cytochrome c from mitochondria
- rRNA transcription
- cardiac septum morphogenesis
- gastrulation
- reactive oxygen species metabolic process
- chromosome organization
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- negative regulation of transforming growth factor beta receptor signaling pathway
- regulation of fibroblast apoptotic process
- transforming growth factor beta receptor signaling pathway
- autophagy
- entrainment of circadian clock by photoperiod
- thymocyte apoptotic process
- positive regulation of thymocyte apoptotic process
- cellular response to hypoxia
- regulation of cell cycle
- response to gamma radiation
- positive regulation of intrinsic apoptotic signaling pathway
- embryonic organ development
- regulation of apoptotic process
- negative regulation of DNA replication
- macromitophagy
- tumor necrosis factor-mediated signaling pathway
- B cell lineage commitment
- somitogenesis
- positive regulation of gene expression
- DNA damage response, signal transduction by p53 class mediator
- response to X-ray
- mRNA transcription
- response to antibiotic
- negative regulation of proteolysis
- ER overload response
- positive regulation of execution phase of apoptosis
- negative regulation of transcription from RNA polymerase II promoter
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- response to ischemia
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- necroptosis
- glucose catabolic process to lactate via pyruvate
- cellular response to UV
- viral reproduction
- cellular response to ionizing radiation
- oxidative stress-induced premature senescence
- cellular response to actinomycin D
- interferon-gamma-mediated signaling pathway
- hemopoietic stem cell differentiation
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- T cell proliferation involved in immune response
- cellular response to xenobiotic stimulus
- glial cell proliferation
- negative regulation of telomere maintenance via telomerase
- protein stabilization
CELLULAR COMPONENT
Where in the cell the gene product is active
- nuclear body
- site of double-strand break
- PML body
- endoplasmic reticulum
- nucleolus
- chromatin
- nucleoplasm
- replication fork
- nucleus
- transcription factor complex
- germ cell nucleus
- centrosome
- cytoplasm
- mitochondrial matrix
- transcriptional repressor complex
- mitochondrion
- cytosol
- nuclear matrix
- macromolecular complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- protease binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- mRNA 3'-UTR binding
- sequence-specific DNA binding transcription factor activity
- p53 binding
- copper ion binding
- protein heterodimerization activity
- chaperone binding
- TFIID-class transcription factor binding
- protein phosphatase 2A binding
- histone deacetylase regulator activity
- identical protein binding
- zinc ion binding
- histone deacetylase binding
- core promoter proximal region sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- core promoter sequence-specific DNA binding
- DNA binding
- ubiquitin protein ligase binding
- protein binding
- receptor tyrosine kinase binding
- enzyme binding
- 14-3-3 protein binding