Target List
Beta-Amyloid Generation, Oligomerization, Clearance & Degradation
Secretases
ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2
Other Peptidases
IDE, PLAT (TPA), PLAU (UPA), PLG
Endocytosis
APLP1, APP, LRP1, LRP6, LRP8
Other Beta-Amyloid Metabolism Genes
A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1
Cytoskeleton Regulators
APOE, MAP2, MAPT, PKP4, PRKCI
Synaptic Formation
ACHE, APBA1 (MINT1), APBB1, APBB2, APOE, BDNF, CHAT
Lipid Metabolism
ABCA1, APOA1, APOE, CLU, HSD17B10, INS, LPL, LRP1, LRP8, SNCB
Apoptosis
APLP1, APP, CASP3, CASP4, CLU, EP300, ERN1, IL1A, MAPT, MPO, NAE1, PRKCA, PRKCE, PRKCZ, PSEN1, PSEN2, SNCA
Cell Cycle
APBB1, APBB2, CDK1, CDK5, CDKL1, ERN1, EP300, IL1A, NAE1, PRKCA
Cell Signaling Molecules
WNT Signaling
GSK3A, GSK3B, LRP6
Notch Signaling
ADAM10, APH1A, NCSTN, PSEN1, PSEN2
G-Protein Coupled Receptor Signaling
APLP2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG11, GNG3, GNG4, GNGT1, GNGT2, NTRK1, NTRK2
Intracellular Signaling
APBA3, APBB2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2
Other Cell Signaling Molecules
GAP43, GNB2, IDE, IL1A, INSR, NAE1, PLAU (UPA)
Transcriptional Regulation
APBB1, APBB2, EP300, ERN1
Oxidative Stress
HSD17B10, MPO, UQCRC1, UQCRC2
Proteases & Protease Inhibitors
ADAM10, APLP2, APP, CAPN1, CTSC, CTSD, CTSG, CTSL, SERPINA3, UQCRC2