Sele Gene Summary [Rat]
Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in leukocyte migration and response to cytokine. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sele |
| Official Name | selectin E [Source:RGD Symbol;Acc:3654] |
| Ensembl ID | ENSRNOG00000002723 |
| Bio databases IDs | |
| Aliases | selectin E |
| Synonyms | CD62E, ELAM, ELAM-1, ESEL, E-selectin, LECAM2, selectin E, selectin, endothelial cell, SELECTIN E precursor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sele often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- complement binding domain
- extracellular domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- enzyme binding
- signal sequence hydrophobic region
- protein binding
- EGF-like domain
- consensus repeat domain
- CCP
- binding protein
- cytoplasmic domain
- transmembrane domain
- hinge domain
- Lectin C-type domain
- Sushi repeat (SCR repeat)
- carbohydrate binding
- transmembrane receptor
- EGF repeat
- SUSHI repeat
- lectin domain
Pathways
Biological processes and signaling networks where the Sele gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- cancer
- epithelial cancer
- epithelial neoplasia
- fibrosis
- coronary artery disease
- acute myeloid leukemia
- panhypopituitarism - X-linked
- edema
regulated by
- Na+
- BAPTA-AM
- progesterone
- IL1
- lipopolysaccharide
- Influenza virus
- TNF
- p38 MAPK
- lipoxin A4
- polyphosphate
role in cell
- activation
- killing
- phosphorylation in
- inhibition
- cell rolling
- quantity
- adhesion
- growth
- recruitment
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endothelial microparticle
- cortical cytoskeleton
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- caveolae
- membrane rafts
- clathrin-coated pits
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sele gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- positive regulation of receptor internalization
- heterophilic cell-cell adhesion
- leukocyte cell-cell adhesion
- actin filament-based process
- positive regulation of leukocyte migration
- leukocyte migration involved in inflammatory response
- inflammatory response
- response to interleukin-1
- regulation of inflammatory response
- response to lipopolysaccharide
- leukocyte tethering or rolling
- calcium-mediated signaling
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- extracellular space
- caveola
- perinuclear region of cytoplasm
- coated pit
- membrane raft
- external side of plasma membrane
- plasma membrane
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- protein binding
- transmembrane signaling receptor activity
- metal ion binding
- phospholipase binding
- sialic acid binding