Basal cell carcinoma (BCC) is the most common form of skin cancer. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling.Ligand-dependent signaling by Hedgehog (Hh) homologs proceeds through association with the Patched receptor. This association relieves the Patched-mediated inhibition of the SMO receptor. Signaling via the SMO receptor releases the transcription factor Gli from an inhibitory cytoplasmic multiprotein complex...