IL16
IL16 Gene Summary
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Details
| Type | Processed Transcript |
| Official Symbol | IL16 |
| Official Name | interleukin 16 [Source:HGNC Symbol;Acc:HGNC:5980] |
| Ensembl ID | ENSG00000172349 |
| Bio databases IDs | |
| Aliases | interleukin 16, prointerleukin 16, lymphocyte chemoattractant factor |
| Synonyms | interleukin 16,LCF,lymphocyte chemoattractant factor,mKIAA4048,NIL16,PRIL16 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- nuclear localization sequence
- canonical PDZ domain
- protein binding
- cytokine
- PDZ domain
- cpPDZ_Deg_HtrA-like
- pro domain
- CD4 receptor binding
Pathways
Biological processes and signaling networks where the IL16 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PPP1R12B
- TEPSIN
- KCTD13
- ATN1
- EWSR1
- KIF16B
- ZNF474
- SPRED1
- WFS1
- ZNF148
disease
- neoplasia
- rheumatoid arthritis
- peripheral arterial disease
- cardiac fibrosis
- systemic lupus erythematosus
- sarcoidosis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- tuberculosis
regulated by
- tretinoin
- CDKN1A
- IL16
- CASP3
- IL17A
- dimaprit
- TNF
- CSF2
- RARA
- FAS
regulates
- IL4
- CDKN1B
- FOS
- BCL2L1
- Ca2+
- IL2RA
- FOXP3
- IL6
- CXCR3
- Ccr5
role in cell
- proliferation
- survival
- formation
- migration
- function
- production in
- cellular infiltration by
- chemotaxis
- recruitment
- chemoattraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell periphery
- intracellular space
- perinuclear region
- focal adhesions
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- actomyosin filament
- Flemming body
- cytosol
- perinuclear space
- nuclear speckles
- neurites
- myosin stress fibers
- actin stress fibers
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IL16 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of interleukin-12 production
- immune response
- signal transduction
- positive regulation of inflammatory response
- positive regulation of interleukin-1 alpha production
- leukocyte chemotaxis
- regulation of calcium ion transport
- positive regulation of interleukin-6 production
- induction of positive chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- focal adhesion
- nuclear speck
- cytosol
- extracellular region
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- CD4 receptor binding
- cytokine activity