QuantiNova LNA Probe PCR Focus Panel Human Cellular Senescence | GeneGlobe

Product Specification

Target List

Senescence Pathway

ATMBMI1CCND1CCNE1CDK2CDK4CDK6CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)CDKN2D (p19-INK4D)CHEK1CHEK2 (RAD53)E2F1E2F3ETS1ETS2MDM2RB1RBL2TP53 (p53)TWIST1

Senescence Initiators

p53 Signaling

Interferon Signaling

ALDH1A3 (RALDH3)CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)EGR1IFNGIGFBP3IGFBP7IRF3IRF5IRF7NFKB1RB1SERPINB2 (PAI-2)

Insulin Growth Factor (IGF) Related

IGF1IGF1RIGFBP3IGFBP5IGFBP7

MAP Kinase Signaling

HRASMAP2K1MAP2K3 (MEK3)MAP2K6 (MEK6, MKK6)MAPK14 (p38ALPHA)

Oxidative Stress

ALDH1A3 (RALDH3)HRASMAPK14 (p38ALPHA)NOX4PRKCDSOD1SOD2

DNA Damage & Repair

ATMGADD45ANBNPCNATERF2TERTTP53BP1

Senescence Responses

p53 Effectors

ALDH1A3 (RALDH3)E2F1HRASIGFBP3MYC

p21 Effectors

p16 Effectors

Cytoskeleton Regulators

AKT1FN1HRASPIK3CA (p110-alpha)PLAU (UPA)SERPINE1 (PAI-1)SPARCTHBS1 (TSP-1)VIM

Cell Adhesion Molecules

CD44COL1A1COL3A1TGFB1TGFB1I1THBS1 (TSP-1)

Other Senescence Response Genes

Product Resources

Download Target List

Array Layout for PCR Plates

File Size: 153.26 KBLanguage: English

Array Layout for Rotor-Gene Q

File Size: 153.4 KBLanguage: English

Resources

QuantiNova LNA Probe PCR Handbook

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