Ccl24 Gene Summary [Rat]
Predicted to enable CCR3 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including eosinophil chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Predicted to act upstream of or within chemotaxis and positive regulation of eosinophil migration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma and rhinitis. Orthologous to human CCL24 (C-C motif chemokine ligand 24). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl24 |
| Official Name | C-C motif chemokine ligand 24 [Source:RGD Symbol;Acc:1310245] |
| Ensembl ID | ENSRNOG00000031162 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 24 |
| Synonyms | C-C motif chemokine ligand 24, CKb-6, Eotaxin-2, MPIF-2, SCYA24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccl24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- receptor agonist activity
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl24 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- rheumatoid arthritis
- weight loss
- hyperplasia
- systemic sclerosis
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- asthma
- sarcoidosis
- angioimmunoblastic T-cell lymphoma
role in cell
- quantity
- activation in
- proliferation
- expression in
- apoptosis
- accumulation
- migration
- chemotaxis
- number
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccl24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- signal transduction
- positive regulation of inflammatory response
- cell-cell signaling
- positive regulation of angiogenesis
- positive regulation of GTPase activity
- positive regulation of eosinophil migration
- chemotaxis
- inflammatory response
- immune response
- chemokine-mediated signaling pathway
- eosinophil chemotaxis
- positive regulation of actin filament polymerization
- positive regulation of endothelial cell proliferation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- CCR chemokine receptor binding
- protein binding
- CCR3 chemokine receptor binding
- receptor agonist activity
- chemokine activity