Hoxb2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including central nervous system development; embryonic skeletal system morphogenesis; and regionalization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; embryo ectoderm; embryo mesenchyme; metanephros; and nervous system. Orthologous to human HOXB2 (homeobox B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Hoxb2 |
| Official Name | homeobox B2 [Source:MGI Symbol;Acc:MGI:96183] |
| Ensembl ID | ENSMUSG00000075588 |
| Bio databases IDs | |
| Aliases | homeobox B2 |
| Synonyms | homeobox B2, HOX2, Hox-2.8, HOX2H, Hoxbes2, K8, LOC100365058 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- tankyrase binding domain
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- pancreatic intraepithelial neoplasm
- pancreatic intraepithelial neoplasia
- pancreatic cancer
- dyspnea
- Crohn disease
role in cell
- migration
- differentiation
- number
- abnormal morphology
- transactivation in
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rhombomere 4 development
- nervous system development
- anterior/posterior pattern specification
- facial nerve structural organization
- rhombomere 3 development
- morphogenesis of an epithelial sheet
- positive regulation of transcription from RNA polymerase II promoter
- embryonic skeletal system morphogenesis
- dorsal/ventral pattern formation
- neural nucleus development
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity