Growth Hormone(GH) and Insulin-Like Growth Factor-1(IGF-1) are two important anabolic hormones that regulate metabolic processes including protein synthesis in almost all tissues throughout the lifespan of mammals. GH is required for normal postnatal growth, having a critical role in bone growth as well as important regulatory effects on protein, carbohydrate and lipid metabolism. The physiological effects of GH are brought about by the Growth hormone receptor (GHR).Biologically active GH binds to two of its transmembrane receptors: GHRs, causes dimerization of GHR, activation of the GHR-associated JAK2, and tyrosyl phosphorylation of both JAK2 and GHR. These events recruit and/or activate a variety of signaling molecules, including MAPKs, IRS1, PI3K, DAG, PKC, and STATs...