GNB1
GNB1 Gene Summary
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | GNB1 |
| Official Name | G protein subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:4396] |
| Ensembl ID | ENSG00000078369 |
| Bio databases IDs | |
| Aliases | G protein subunit beta 1, transducin beta chain 1, guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
| Synonyms | AA409223,beta subunit SIGNAL TRANSDUCING PROTEINS GS/GI,C77571,G beta1,G protein subunit beta 1,G protein subunit β 1,G protein β 1,GTP-Binding Regulatory Protein, Beta1 Subunit,GUANINE NUCLEOTIDE binding protein beta1,guanine nucleotide binding protein (G protein), beta 1,guanine nucleotide binding protein (G protein), β 1,HG2A,MDS,MRD42,Transducin beta chain 1,Transducin β chain 1,β subunit SIGNAL TRANSDUCING PROTEINS GS/GI |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40 repeats
- alkylglycerophosphoethanolamine phosphodiesterase
- WD domain, G-beta repeat
- spectrin binding
- enzyme binding
- GTPase
- WD40
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the GNB1 gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- Gαs Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Phospholipase C Signaling
- Phototransduction Pathway
- Protein Kinase A Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- BTK
- PDGFRA
- ESR2
- FKBP8
- GNGT1
- GNG5
- APOA1
- carazolol
- L-alpha-palmitoyloleolyl-phosphatidylcholine
disease
- chronic lymphocytic leukemia
- hereditary disorder
- myelodysplastic syndrome
- mental retardation
- Huntington disease
- microcephaly
- duodenal-type follicular lymphoma
- follicular non-Hodgkin disease
- duodenal cancer
- tumorigenesis
regulated by
- NRL
- GNG13
- HRAS
- beta-estradiol
- ICMT
- APP
- PDCL
- cocaine
- GPSM3
- Tax
regulates
- IL1B
- BTK
- Ca2+
- AKT
- ERK
- AKT1
- SRC
- cyclic AMP
- MAPK
- guanosine 5'-O-(3-thiotriphosphate)
role in cell
- activation in
- apoptosis
- proliferation
- cell viability
- expression in
- degeneration
- formation
- activity
- binding
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- membrane fraction
- Cytoplasm
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- synaptic vesicles
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- membrane rafts
- pseudopodia
- perikaryon
- dendrites
- rod outer segments
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the GNB1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell proliferation
- adenylate cyclase-activating dopamine receptor signaling pathway
- sensory perception of taste
- G-protein coupled receptor signaling pathway
- retina development in camera-type eye
- signal transduction
- cellular response to catecholamine stimulus
- G-protein coupled acetylcholine receptor signaling pathway
- Ras protein signal transduction
- phospholipase C-activating G-protein coupled receptor signaling pathway
- cellular response to prostaglandin E stimulus
CELLULAR COMPONENT
Where in the cell the gene product is active
- heterotrimeric G-protein complex
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- synapse
- plasma membrane
- lysosomal membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- GTPase binding
- GTPase activity
- receptor signaling complex scaffold activity