Target List
Oxidative Stress
FTH1, GCLC, GCLM, GSR, GSTP1, HMOX1, NQO1, PRDX1, SQSTM1, TXN, TXNRD1
Hypoxia Signaling
ADM, ARNT, BNIP3L, CA9, EPO, HMOX1, LDHA, MMP9, SERPINE1 (PAI-1), SLC2A1, VEGFA
Osmotic Stress
AKR1B1, AQP1, AQP2, AQP4, CFTR, EDN1, HSPA4L (OSP94), NFAT5, SLC5A3
Cell Death
Apoptosis
CASP1 (ICE), FAS, MCL1, TNFRSF10A (TRAIL-R), TNFRSF10B (DR5), TNFRSF1A (TNFR1)
Autophagy
ATG5, ATG7, ATG12, BECN1, FAS, ULK1
Necrosis
FAS, GRB2, PARP1 (ADPRT1), PVR, RIPK1, TNFRSF10A (TRAIL-R), TNFRSF1A (TNFR1), TXNL4B
Inflammatory Response
CCL2 (MCP-1), CD40LG, CRP, IFNG, IL1A, IL1B, IL6, CXCL8 (IL8), TLR4, TNF
DNA Damage & Repair
Cell Cycle Arrest & Checkpoints
CDKN1A (p21CIP1, WAF1), CHEK1, CHEK2 (RAD53), DDIT3 (GADD153, CHOP), HUS1, MRE11, NBN, RAD17, RAD9A
Other DNA Damage Responses
ATM, ATR, DDB2, GADD45A, GADD45G, RAD51, TP53 (p53), XPC
Unfolded Protein Response
ATF4, ATF6, ATF6B, BBC3 (PUMA), BID, CALR, DDIT3 (GADD153, CHOP), DNAJC3, HSP90AA1, HSP90B1, HSPA4 (HSP70), HSPA5 (GRP78)