Target List
Cholestasis
ABCB1 (MDR1, PGY1), ABCB4, ABCC2 (MRP2, cMOAT), ABCC3 (MRP3, MOAT-D), ATP8B1, ICAM1, SLC51A, PDYN, RDX
Steatosis
Up-Regulated in Steatosis
CD36, FASN, LPL, SCD
Down-Regulated in Steatosis
PPARA, SREBF1
Phospholipidosis
Up-Regulated in Phospholipidosis
ASAH1, FABP1, HPN, LSS, MRPS18B, S100A8, SERPINA3, WIPI1
Down-Regulated in Phospholipidosis
SLC2A3, TAGLN
Regulated in Phospholipidosis
ABCB1 (MDR1, PGY1), TIMM10B
Hepatotoxicity
Up-Regulated in Hepatotoxicity
ALDOA, APEX1, BTG2, CASP3, CCNG1, CRYL1, DDIT4L (REDD2), DNAJB11, DNAJC3, GADD45A, GCLC, GSR, HMOX1, HYOU1, KRT18, KRT8, NQO1, PLA2G12A, SLC17A3, TXNRD1, YRDC
Down-Regulated in Hepatotoxicity
AVPR1A, BHMT, CA3, CXCL12 (SDF1), CYP1A2, FADS1, FMO1, HAO2, IGFALS, MBL2, RB1, THRSP
Regulated in Hepatotoxicity
ABCB11, TIMM10B, MAOB, PYGL
Nongenotoxic Hepatocarcinogenicity
Up-Regulated in Nongenotoxic Hepatocarcinogenicity
ALDOA, APEX1, BTG2, CCNG1, CDKN1A (p21CIP1, WAF1), DDX39A, KRT8, KRT18, MRPS18B, TXNRD1
Necrosis
Up-Regulated in Necrosis
CD68, COL4A1, IL6ST (GP130), IPO4, MAP3K6, NUS1, OSMR, PSME3, SERPINE1 (PAI-1), SKIL, SLC39A6, CEMIP2
Down-Regulated in Necrosis
CDC14B, EMC9, FAM214A, L2HGDH, LGR5, MCM10, MLXIPL, RHBG
Regulated in Necrosis
CDKN1A (p21CIP1, WAF1), DDX39A