PSMC3 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PSMC3 |
| Official Name | proteasome 26S subunit, ATPase 3 [Source:HGNC Symbol;Acc:HGNC:9549] |
| Ensembl ID | ENSG00000165916 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, ATPase 3, Tat-binding protein-1 |
| Synonyms | DCIDP, Proteasome 26S Subunit 3, Proteasome 26s subunit atpase 3, proteasome 26S subunit, ATPase 3, proteasome (prosome, macropain) 26S subunit, ATPase 3, RPT5, S6', S6A, TBP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome subunit P45 family
- Proteasomal ATPase OB C-terminal domain
- ATP-binding domain
- isomerase
- leucine zipper domain
- coiled-coil domain
- enzyme
- protein binding
- identical protein binding
- AAA+ lid domain
- helicase domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- ATPase domain
- HbYX motif
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the PSMC3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- non-insulin-dependent diabetes mellitus
- venous thromboembolism
- deafness, cataract, impaired intellectual development, and polyneuropathy
- neuroticism
- depressive disorder
- neurodevelopmental disorder
- hypertension
- hereditary disorder
- infection by HIV-1
role in cell
- expression in
- proliferation
- growth
- transcription in
- colony formation
- assembly in
- cell viability
- stabilization in
- degradation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic mRNA processing body
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- perinuclear region
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of transcription from RNA polymerase II promoter
- modulation by host of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- membrane
- cytoplasmic mRNA processing body
- cytosol
- proteasome accessory complex
- proteasome complex
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding