Bcl2l11 Gene Summary [Mouse]
Enables microtubule binding activity and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including apoptotic signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte homeostasis. Located in membrane and mitochondrion. Part of Bcl-2 family protein complex. Is expressed in several structures, including hair outer root sheath; hemolymphoid system gland; metanephros; neural tube; and trunk mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2l11 |
| Official Name | BCL2-like 11 (apoptosis facilitator) [Source:MGI Symbol;Acc:MGI:1197519] |
| Ensembl ID | ENSMUSG00000027381 |
| Bio databases IDs | |
| Aliases | BCL2-like 11 (apoptosis facilitator) |
| Synonyms | 1500006F24RIK, BAM, BCL2 like 11, BIM, BOD, BODL, FLJ23507, LOC150819 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl2l11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Akt phosphorylation site
- protein kinase binding
- Bcl-2 homology 3 domain
- protein binding
- Bcl-x interacting, BH3 domain
- phosphorylation site
- Bim protein N-terminus
- Jnk phosphorylation site
Pathways
Biological processes and signaling networks where the Bcl2l11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- vasculitis
- delayed hypersensitive reaction
- non-Hodgkin disease
- neoplasia
- Sézary syndrome
- Crohn disease
- breast carcinoma
- systemic lupus erythematosus
- cancer
regulated by
- APP
- cyclosporin A
- glutathione
- erlotinib
- adenosine triphosphate
- Immunoglobulin
- dexamethasone
- recombinant fusion protein
- TP53
- chloroquine
role in cell
- expression in
- proliferation
- binding in
- replication in
- cell cycle progression
- cell death
- apoptosis
- colony formation
- differentiation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- microtubule fractions
- nuclear fraction
- microtubule aster fraction
- soluble fraction
- membrane fraction
- insoluble fractions
- mitochondrial fraction
- intracellular membrane-bounded organelle
- intracellular membranes
- outer membranes
- cellular membrane
- Nucleus
- Mitochondria
- microtubules
- granules
- cytosol
- mitochondrial outer membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl2l11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- post-embryonic development
- spleen development
- positive regulation of cell cycle
- odontogenesis of dentin-containing tooth
- myeloid cell homeostasis
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of neuron apoptotic process
- thymus development
- T cell homeostasis
- developmental pigmentation
- kidney development
- in utero embryonic development
- thymocyte apoptotic process
- apoptotic process
- positive regulation of protein complex assembly
- cell-matrix adhesion
- spermatogenesis
- positive regulation of fibroblast apoptotic process
- positive regulation of release of cytochrome c from mitochondria
- regulation of organ growth
- DNA damage response, signal transduction resulting in induction of apoptosis
- regulation of apoptotic process
- B cell homeostasis
- meiosis I
- mammary gland development
- cellular response to glucocorticoid stimulus
- ear development
- positive regulation of apoptotic process
- regulation of developmental pigmentation
- positive regulation of T cell apoptotic process
- tube formation
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- Bcl-2 family protein complex
- mitochondrion
- cytosol
- endomembrane system
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- microtubule binding