GeneDetails_Summary_Title
Enables PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of cell-matrix adhesion. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including bone; central nervous system; jaw; thymus primordium; and vomeronasal organ. Orthologous to human PLEKHA2 (pleckstrin homology domain containing A2). [provided by Alliance of Genome Resources, Jul 2025]
GeneDetails_GeneDetails_Title
| Gene_type | Protein Coding |
| Official_symbol | Plekha2 |
| Official_name | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 [Source:MGI Symbol;Acc:MGI:1928144] |
| Ensembl_gene_ID | ENSMUSG00000031557 |
| BioDatabase_IDs | |
| Aliases_list | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 |
| Synonyms | 6430512N22Rik, pleckstrin homology domain containing A2, pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2, TAPP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
GeneDetails_ProteinDomains_Title
GeneDetails_ProteinDomains_Description
- binding protein
- laminin binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- fibronectin binding
- PDZ-domain binding
GeneDetails_Pathways_Title
GeneDetails_Pathways_Description
GeneDetails_TopFindings_Title
GeneDetails_TopFindings_Description
disease
- glomerulonephritis
- COVID-19
- neuroticism
phenotypes
- no abnormal phenotype detected
role in cell
- expression in
- proliferation
- phosphorylation in
- adhesion
- frequency
- respiration
- spare respiratory capacity
- glycolysis in
- development
- activity
GeneDetails_SubcellularExpressions_Title
GeneDetails_SubcellularExpressions_Description
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
GeneDetails_GeneOntologyAnnotations_Title
GeneDetails_GeneOntologyAnnotations_Description
Biological Process
geneOntologyAnnotations_BIOLOGICAL_PROCESS_Description
- positive regulation of cell-matrix adhesion
Cellular Component
geneOntologyAnnotations_CELLULAR_COMPONENT_Description
- nucleus
- cytoplasm
- membrane
- macromolecular complex
- plasma membrane
Molecular Function
geneOntologyAnnotations_MOLECULAR_FUNCTION_Description
- protein binding
- fibronectin binding
- PDZ domain binding
- lipid binding
- phosphatidylinositol-3,4-bisphosphate binding
- laminin binding