Cog6 Gene Summary [Mouse]
Predicted to be involved in Golgi organization; glycosylation; and retrograde transport, vesicle recycling within Golgi. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Is expressed in retina outer nuclear layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIl. Orthologous to human COG6 (component of oligomeric golgi complex 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cog6 |
| Official Name | component of oligomeric golgi complex 6 [Source:MGI Symbol;Acc:MGI:1914792] |
| Ensembl ID | ENSMUSG00000027742 |
| Bio databases IDs | |
| Aliases | component of oligomeric golgi complex 6 |
| Synonyms | 4933405E16Rik, CDG2L, COD2, component of oligomeric golgi complex 6, mKIAA1134, SHNS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cog6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Conserved oligomeric complex COG6
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
disease
- COVID-19
- asthma
- rheumatoid arthritis
- congenital disorder of glycosylation type 2L
- psoriasis
- multiple sclerosis
- hereditary disorder
- systemic lupus erythematosus
- uterine leiomyoma
- leiomyomatosis
phenotypes
- abnormal bone structure
- abnormal coat/hair pigmentation
- abnormal cornea morphology
- decreased CD4-positive NK T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased Ly6C-positive immature NK cell number
- decreased Ly6C-positive mature NK cell number
- decreased NK T cell number
- decreased NK cell number
- decreased T cell number
- decreased T-helper cell number
- decreased alpha-beta T cell number
- decreased bone mineral content
- decreased effector memory CD8-positive alpha-beta T cell number
- decreased erythrocyte cell number
- decreased grip strength
- decreased hematocrit
- decreased hemoglobin content
- decreased marginal zone B cell number
- decreased mean corpuscular hemoglobin concentration
- decreased memory-marker CD4-negative NK T cell number
- decreased memory-marker CD4-positive NK T cell number
- decreased memory-marker NK cell number
- decreased memory-marker gamma-delta T cell number
- decreased transitional stage T2 B cell number
- increased B-2 B cell number
- increased CD4-negative NK T cell number
- increased CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased CD4-positive alpha beta T cell number
- increased CD4-positive alpha-beta memory T cell number
- increased CD5-positive gamma-delta T cell number
- increased KLRG1+ CD4 alpha beta T cell number
- increased KLRG1+ CD8 alpha beta T cell number
- increased KLRG1-positive CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased KLRG1-positive NK cell number
- increased KLRG1-positive T-helper cell number
- increased Ly6C high monocyte number
- increased anti-nuclear antigen antibody level
- increased circulating alkaline phosphatase level
- increased circulating amylase level
- increased circulating total protein level
- increased effector memory T-helper cell number
- increased eosinophil cell number
- increased follicular B cell number
- increased gamma-delta T cell number
- increased granulocyte number
- increased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased memory-marker NK cell number
- increased memory-marker gamma-delta T cell number
- increased monocyte cell number
- increased plasma cell number
- increased red blood cell distribution width
- vertebral transformation
- abnormal bone mineralization
- abnormal circulating alkaline phosphatase level
- abnormal circulating amylase level
- abnormal coronary sinus connection
- abnormal ductus venosus valve morphology
- abnormal grip strength
- abnormal inferior vena cava morphology
- abnormal inferior vena cava valve morphology
- abnormal liver vasculature morphology
- abnormal mean corpuscular hemoglobin concentration
- abnormal vertebral artery topology
- abnormal vitelline vein connection
- dual inferior vena cava
- fusion of vertebral arches
- intracerebral hemorrhage
- muscular ventricular septal defect
- no abnormal phenotype detected
- thin hypoglossal nerve
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cog6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosylation
- Golgi organization
- protein transport
- intra-Golgi vesicle-mediated transport
- retrograde transport, vesicle recycling within Golgi
Cellular Component
Where in the cell the gene product is active
- Golgi transport complex
- Golgi membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding