Cog6 Gene Summary [Mouse]
Predicted to be involved in Golgi organization; glycosylation; and retrograde transport, vesicle recycling within Golgi. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Is expressed in retina outer nuclear layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIl. Orthologous to human COG6 (component of oligomeric golgi complex 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cog6 |
| Official Name | component of oligomeric golgi complex 6 [Source:MGI Symbol;Acc:MGI:1914792] |
| Ensembl ID | ENSMUSG00000027742 |
| Bio databases IDs | |
| Aliases | component of oligomeric golgi complex 6 |
| Synonyms | 4933405E16Rik, CDG2L, COD2, component of oligomeric golgi complex 6, mKIAA1134, SHNS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cog6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Conserved oligomeric complex COG6
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- asthma
- rheumatoid arthritis
- congenital disorder of glycosylation type 2L
- psoriasis
- multiple sclerosis
- hereditary disorder
- systemic lupus erythematosus
- uterine leiomyoma
- leiomyomatosis
regulates
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cog6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosylation
- Golgi organization
- protein transport
- intra-Golgi vesicle-mediated transport
- retrograde transport, vesicle recycling within Golgi
Cellular Component
Where in the cell the gene product is active
- Golgi transport complex
- Golgi membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding