PLEKHA2
PLEKHA2 Gene Summary
Enables fibronectin binding activity; laminin binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in positive regulation of cell-matrix adhesion. Located in cytoplasm and membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLEKHA2 |
| Official Name | pleckstrin homology domain containing A2 [Source:HGNC Symbol;Acc:HGNC:14336] |
| Ensembl ID | ENSG00000169499 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing A2, tandem PH Domain containing protein-2 |
| Synonyms | 6430512N22Rik,pleckstrin homology domain containing A2,pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2,TAPP2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- laminin binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- fibronectin binding
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the PLEKHA2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TRIM25
- RALA
- VDAC2
- YWHAG
- TRIM67
- DDB1
- COG6
- SEC24C
- YWHAB
- TEPSIN
disease
- glomerulonephritis
- COVID-19
- neuroticism
regulated by
- FCGR2
- wortmannin
- LY294002
- IgM
- PLEKHA2
- CD2
- PIK3 p110
- TP63
- levodopa
- SB-431542
regulates
- AKT
- GSK3B
- CD86
- FN1
- PLEKHA2
- 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose
- IgG
- IgG2c
- IgM
- SLC2A1
role in cell
- expression in
- proliferation
- phosphorylation in
- adhesion
- frequency
- respiration
- spare respiratory capacity
- glycolysis in
- development
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PLEKHA2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of cell-matrix adhesion
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- macromolecular complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- fibronectin binding
- PDZ domain binding
- lipid binding
- phosphatidylinositol-3,4-bisphosphate binding
- laminin binding