Trim25 Gene Summary [Mouse]
Predicted to enable RIG-I binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in host-mediated suppression of symbiont invasion; regulation of protein localization; and suppression of viral release by host. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human TRIM25 (tripartite motif containing 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim25 |
| Official Name | tripartite motif-containing 25 [Source:MGI Symbol;Acc:MGI:102749] |
| Ensembl ID | ENSMUSG00000000275 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 25 |
| Synonyms | EFP, estrogen-responsive finger, RNF147, TRIM25 alpha, TRIM25 α, tripartite motif-containing 25, Z147, Zfp147, ZNF147 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- B box/coiled coil domain
- coiled-coil domain
- enzyme
- Ring finger domain
- protein binding
- receptor binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Box B domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Trim25 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- head and neck neoplasia
- organismal death
- glioma
- glioma formation
- glioblastoma
- glioblastoma cancer
- idiopathic inflammatory myopathy
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- myopia
role in cell
- activation in
- proliferation
- apoptosis
- growth
- differentiation
- signaling
- ferroptosis
- invasion by
- cell cycle progression
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear body
- Nucleus
- cytoplasmic particles
- granules
- cytosol
- nucleoplasm
- nuclear bodies
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- protein K48-linked ubiquitination
- response to vitamin D
- regulation of protein localization
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- response to oxidative stress
- cytoplasmic pattern recognition receptor signaling pathway
- regulation of viral entry into host cell
- release of virus from host
- negative regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- innate immune response
- RIG-I signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasmic stress granule
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- RNA binding
- transcription coactivator activity
- metal ion binding
- cadherin binding
- RIG-I binding
- ligase activity